Advances in psoriasis physiopathology and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS)

Sala, M.; Elaı̈ssari, Abdelhamid; Fessi, Hatem

doi:10.1016/j.jconrel.2016.07.003

Cited by 84 publications

(51 citation statements)

References 146 publications

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“…The main pathological features of psoriatic lesions are aberrant terminal differentiation and hyperproliferation of epidermal keratinocytes marked inflammatory infiltration, and pathological angiogenesis. [ 168 ] The excessive growth of keratinocytes in psoriatic lesions is similar to the characteristic malignant proliferation of tumor cells. [ 12,127 ] The primary application of the plasma in cancer therapy suggests its significant value in the psoriasis treatment.…”

Section: Applications In Dermatologymentioning

confidence: 99%

Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Liu

Zhang

et al. 2020

Plasma Processes & Polymers

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Recently, cold atmospheric pressure plasmas (CAPs) have provided many new opportunities in dermatology by providing a multimodal action of reactive agents (RA). This review critically examines the generation, transport, and physical effects induced by CAPs in dermatologic treatments. We introduce the most suitable plasma sources, which provide a multitude of physical effects on the skin without any electric or thermal shocks. The mechanisms of generation and transport of the key reactive species are introduced and examined from the viewpoint of their applications in dermatology. Special attention is paid to study the “plasmaporation” effect, which enables RA penetration through healthy and damaged skin. Plausible physical mechanisms involved in the CAP treatment of some of the most common skin diseases are analyzed.

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Section: Applications In Dermatologymentioning

confidence: 99%

Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Liu

Zhang

et al. 2020

Plasma Processes & Polymers

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“…Psoriatic skin with the characteristics of thickening and abnormal maturation of the SC, lipid imbalance, and deficiency of natural moisturizers hinders drug penetration and limits therapeutic efficacy. 9 A novel and improved percutaneous delivery system to overcome the SC barrier of psoriatic skin is vital to antipsoriatic drug for topical therapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Wan

Pan

Long

et al. 2017

IJN

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The hybrid system based on nanoparticles (NPs) self-assembled by the conjugations of hyaluronic acid with cholesterol (HA–Chol NPs) combined with nicotinamide (NIC) for tacrolimus (FK506), ie, FK506 NPs–NIC, has been confirmed to exhibit a significant synergistic effect on FK506 permeation through and into intact skin; thus, it may be a promising approach for FK506 to effectively treat skin diseases. The aim of this study was to evaluate its potential for the treatment of psoriasis. In vitro permeation through the psoriatic skin was carried out, and the results revealed that the combination of NPs with NIC exhibited a significant synergistic effect on FK506 deposition within the psoriatic skin (3.40±0.67 μg/cm 2 ) and penetration through the psoriatic skin (30.86±9.66 μg/cm 2 ). The antipsoriatic activity of FK506 NPs–NIC was evaluated through the treatment for imiquimod (IMQ)-induced psoriasis. The psoriasis area and severity index (PASI) score demonstrated that FK506 HA–Chol NPs–NIC exerted the effect on ameliorating the skin lesions comparable to clobetasol propionate (a positive drug for psoriasis) and superior to commercial FK506 ointment (Protopic ® ), and the histological study showed that it presented a synergistic effect on antipsoriasis after FK506 incorporation into NPs combined with NIC hydrotropic system, which might ultimately increase the therapeutic effect and minimize the systemic side effects by reducing the overall dose of FK506. RAW 264.7 cell uptake presented the enhancement of drugs delivered into cells by HA–Chol NPs–NIC. The antiproliferative activity on HaCaT cells identified that FK506 HA–Chol NPs–NIC exhibited significant inhibiting effects on HaCaT proliferation. The results support that the combination of HA–Chol NPs with NIC is a promising approach for FK506 for the treatment of psoriasis.

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“…To date, there is still no therapy capable of curing or completely controlling the condition. Key pathogenetic events in psoriatic lesions include aberrant terminal differentiation and hyperproliferation of epidermal keratinocytes, marked inflammatory infiltration, and pathological angiogenesis . The excessive growth of keratinocytes in psoriatic lesions is similar to the characteristic malignant proliferation of tumor cells.…”

Section: Effects Of Cap On Psoriasismentioning

confidence: 99%

Medical applications of nonthermal atmospheric pressure plasma in dermatology

Gan

Zhang

Poorun

et al. 2017

J Deutsche Derma Gesell

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SummaryPlasma is an ionized gas that consists of positively and negatively charged particles, neutral atoms, and photons. Recent developments in plasma sources have made it possible to generate room-temperature plasma in the "open air", thus enabling the application of plasma in vivo. Using nonthermal plasma, active agents can be efficiently delivered to target cells without creating thermal damage. Also known as cold atmospheric pressure plasma (CAP), nonthermal atmospheric pressure plasma offers innovative medical applications. In this context, it has also gained wide attention in the field of dermatology. The complex and variable mixture of active agents in plasma -predominantly reactive oxygen and nitrogen species (ROS, RNS) -can control or trigger complex biochemical reactions, achieving the desired effects in a dose-dependent manner. The objective of the present review is to present potential applications of plasma in dermatology and analyze its potential mechanisms of action.

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Advances in psoriasis physiopathology and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS)

Cited by 84 publications

References 146 publications

Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Cold atmospheric pressure plasmas in dermatology: Sources, reactive agents, and therapeutic effects

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Medical applications of nonthermal atmospheric pressure plasma in dermatology

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