Advances in Prostate Cancer Research and Treatment

Livi, Lorenzo; Isidori, Andrea M.; Sherris, David; Gravina, Giovanni Luca

doi:10.1155/2014/708383

Cited by 1 publication

(1 citation statement)

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“…In order to assess the prognosis of Pca, the cancers are graded based on a scoring system called the Gleason scale (GS) 2 . To date, conventional anatomic imaging techniques of computed tomography (CT), ultrasound, magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are currently used in the common clinical practice to stage men suffering from Pca 8 . The American Joint Committee on Cancer (AJCC) methodology uses the T (tumor extent), N (lymph node invasion), and M (presence or absence of metastasis) classifications to group patients 9 .…”

Section: Introductionmentioning

confidence: 99%

Study of Association of Lysosomal Associated Protein Trans Membrane 4 Beta (Laptm4b) Gene Polymorphism With Prostate Cancer

Chobok¹,

Mohammed²

2019

Int Res J Pharm

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Background: According to Annual Report Iraqi Cancer Registry, prostate cancer were classified within top ten cancers in Iraqi male and composed 6.5 % of all cancer cases. Worldwide studies have shown relationship between LAPTM4B gene polymorphism and risk of prostate cancer. Aim: To study the association of LAPTM4B gene polymorphism with prostate cancer in Iraqi population. Methods: This case control study consisted of 80 prostate cancer patients and 80 healthy individuals as control group. Genotyping of LAPTM4B gene polymorphism is carried out by PCR. DNA was extracted from whole blood and genotyping was achieved with specific primers to amplify gene fragments followed by electrophoresis on agarose gel. Various statistical analyses were applied to analyze the data. Results: The LAPTM4B gene polymorphism was associated with decreased risk of Pca in codominant (OR= 49 %, CI = 0.24 _0.99, P = 0.049, *1/2 versus *1/1) and dominant (OR = 47 %, CI = 0.24 _0.90, P = 0.024, *1/2+*2/2 versus *1/1) inheritance models. Conclusion: Our findings suggest that The LAPTM4B*2 allele significantly decreased the risk of Pca compared to LAPTM4B*1 and consider as protective factor in Iraqi population.

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Section: Introductionmentioning

confidence: 99%