Advances in prognostic models for osteosarcoma risk

Yao, Yi; Wang, Dapeng; Zheng, Li; Zhao, Jinmin; Tan, Manli

doi:10.1016/j.heliyon.2024.e28493

Cited by 1 publication

(1 citation statement)

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“…Although early detection and conventional treatment have improved the survival rate of osteosarcoma, some patients have a worse prognosis due to drug resistance and distant metastasis 8 . Therefore, it is pivotal to explore the molecular mechanisms of osteosarcoma occurrence and progression and uncover the novel treatment 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

Li,

Chen,

Zhou

et al. 2024

Sci Rep

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Osteosarcoma is an aggressive form of bone cancer and affects the health in children and adolescents. Although conventional treatment improves the osteosarcoma survival, some patients have metastasis and drug resistance, leading to a worse prognosis. Therefore, it is necessary to explore the molecular mechanism of osteosarcoma occurrence and progression, which could discover the novel treatment for osteosarcoma. Long noncoding RNAs (lncRNAs) have been reported to regulate osteosarcoma occurrence and malignant progression. LncRNA HOXA-AS3 facilitates the tumorigenesis and progression in a variety of human cancers. However, the underlying mechanism of lncRNA HOXA-AS3-induced oncogenesis is poorly determined in osteosarcoma. To address this point, we utilized several cellular biological strategies and molecular approaches to explore the biological functions and mechanisms of lncRNA HOXA-AS3 in osteosarcoma cells. We found that lncRNA HOXA-AS3 facilitates cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma. In conclusion, lncRNA HOXA-AS3 could be a promising target for osteosarcoma treatment.

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Section: Introductionmentioning

confidence: 99%