Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling of Nanomaterials
Ozlem Ozbek,
Destina Ekingen Genc,
Kutlu O. Ulgen
Abstract:Nanoparticles (NPs) have been widely used to improve the pharmacokinetic properties and tissue distribution of small molecules such as targeting to a specific tissue of interest, enhancing their systemic circulation, and enlarging their therapeutic properties. NPs have unique and complicated in vivo disposition properties compared to small molecule drugs due to their complex multifunctionality. Physiologically based pharmacokinetic (PBPK) modeling has been a powerful tool in the simulation of the absorption, d… Show more
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