Advances in physiological functions and mechanisms of (−)-epicatechin

Qu, Zhihao; Liu, Ailing; Li, Penghui; Liu, Changwei; Xiao, Wenjun; Huang, Jianan; Z, Liu; Zhang, Sheng

doi:10.1080/10408398.2020.1723057

Cited by 66 publications

(34 citation statements)

References 218 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, catechin extracted from green tea-based polyphenol was also associated to rare earth (RE) metal ions to prepare catechin–RE complexes that showed significant anti-biofilm properties against Pseudomonas aeruginosa , Staphylococcus sciuri and Aspergillus niger , acting through the damage of microbial cell membrane [ 42 ]. Epicatechin and its metabolites can enhance muscle performance, improve symptoms of cardiovascular and cerebrovascular diseases, and support human health preventing diabetes and protecting the nervous system [ 43 ]. The presence of a so high amount of catechins and epicatechin in the varieties of sweet pepper resulted still more interesting, taking into account that, in some cases, flavonoid contents of pepper extracts can be enhanced with thermal process, such as by increasing temperature to 65 °C [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Biochemical Characterization of Traditional Varieties of Sweet Pepper (Capsicum annuum L.) of the Campania Region, Southern Italy

et al. 2020

View full text Add to dashboard Cite

Bioactive compounds of different Campania native sweet pepper varieties were evaluated. Polyphenols ranged between 1.37 mmol g−1 and 3.42 mmol g−1, β-carotene was abundant in the red variety “Cazzone” (7.05 μg g−1). Yellow and red varieties showed a content of ascorbic acid not inferior to 0.82 mg g−1, while in some green varieties the presence of ascorbic acid was almost inconsistent. Interrelationships between the parameters analyzed and the varieties showed that ascorbic acid could represent the factor mostly influencing the antioxidant activity. Polyphenol profile was different among the varieties, with a general prevalence of acidic phenols in yellow varieties and of flavonoids in red varieties. Principal Component Analysis, applied to ascorbic acid, total polyphenols and β-carotene, revealed that two of the green varieties (“Friariello napoletano” and “Friariello Sigaretta”) were well clustered and that the yellow variety “Corno di capra” showed similarity with the green varieties, in particular with “Friariello Nocerese”. This was confirmed by the interrelationships applied to polyphenol composition, which let us to light on a clustering of several red and yellow varieties, and that mainly the yellow ”Corno di capra” was closer to the green varieties of “Friariello”.

show abstract

Section: Resultsmentioning

confidence: 99%

Biochemical Characterization of Traditional Varieties of Sweet Pepper (Capsicum annuum L.) of the Campania Region, Southern Italy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Syringic acid and catechin, which are related to methyl syringate and epicatechin, respectively, followed in abundance. Health promoting properties such as antioxidant and antiproliferative activities have been found in all these polyphenols (Gheena & Ezhilarasan, 2019;Natarajan et al, 2019;Qu et al, 2020).…”

Section: Mellissopalynology and Physicochemical Characterization Of Zmentioning

confidence: 99%

Physicochemical characteristics and antiproliferative and antioxidant activities of Moroccan Zantaz honey rich in methyl syringate

et al. 2021

View full text Add to dashboard Cite

“…The activation of the PI3K/AKT pathway can promote the dissociation of Keap1–Nrf2 and the translocation of Nrf2 to the nucleus [ 46 ]. However, in vitro experiments have also found that EC can directly activate Nrf2 to exert its antioxidant effects [ 47 ]. Therefore, this study used ovarian granulosa cells to confirm the antioxidant effect of EC on treating POI through the PI3K/AKT/Nrf2 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

et al. 2021

View full text Add to dashboard Cite

Background: To explore the molecular pharmacological mechanism of (-)-Epicatechin (EC) on the treatment of premature ovarian insufficiency (POI) by network pharmacology method and in vitro experiments. Methods: Relevant potential targets for EC were obtained based on Traditional Chinese Medicine System Pharmacology Database (TCMSP), a bioinformatics analysis tool for molecular mechanism of Traditional Chinese Medicine (BATMAN-TCM) and STITCH databases. The OMIM and GeneCards database were utilized to screen the known POI-related targets, while Cytoscape software was used for network construction and visualization. Then, the Gene Ontology (GO) and Pathway enrichment analysis were carried by the David database. Furthermore, KGN cells were performed to validate the predicted results in oxidative stress (OS) model, and antioxidant effect was examined. Results: A total of 70 potential common targets for EC in the treatment of POI were obtained through network pharmacology. Metabolic process, response to stimulus and antioxidant activity occupied a leading position of GO enrichment. KEGG analysis indicated that PI3K/AKT, TNF, estrogen, VEGF and MAPK signaling pathways were significantly enriched. In addition, cell experiments showed that EC exhibited antioxidant effects in an H2O2-mediated OS model in ovarian granulosa cells by regulating the expression of PI3K/AKT/Nrf2 signaling pathway and multiple downstream antioxidant enzymes. Conclusion: EC could regulate multiple signaling pathways and several biological processes. EC had the ability to downregulate elevated OS level through the PI3K/AKT/Nrf2 signaling pathway and represented a potential novel treatment for POI.

show abstract

Advances in physiological functions and mechanisms of (−)-epicatechin

Cited by 66 publications

References 218 publications

Biochemical Characterization of Traditional Varieties of Sweet Pepper (Capsicum annuum L.) of the Campania Region, Southern Italy

Biochemical Characterization of Traditional Varieties of Sweet Pepper (Capsicum annuum L.) of the Campania Region, Southern Italy

Physicochemical characteristics and antiproliferative and antioxidant activities of Moroccan Zantaz honey rich in methyl syringate

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Contact Info

Product

Resources

About