Advances in Pharmacological Mechanism of Eucommia Ulmoides in Treating Parkinson's Disease

Abstract

Parkinson's disease is a common clinical neurodegenerative disease, mainly manifested by motor retardation, quiescence tremor, myotonia, etc., which seriously affects patients' physical and mental health and quality of life.Eucommia ulmoides is a commonly used traditional Chinese medicine for Parkinson's disease, which has the effect of tonifying liver and kidney, strengthening muscles and bones.Through the analysis of several drug components, animal and in vitro cell experiments, and the in-depth exploration of network pharmacology, it was found that Eucommia ulmoides contained a variety of effective active ingredients, such as peach-leaf corallin, eucommia ulmoides polysaccharide, protocatechuic acid, chlorogenic acid, caffeic acid, geniposide, etc.It can be used to treat Parkinson's disease by anti-neuroinflammation, anti-oxidative stress, inhibition of apoptosis and enhancement of nerve autophagy.In this paper, the active components of Eucommia ulmoides and their effects on receptor proteins and signaling pathways were summarized, so as to clarify the pharmacological mechanism of Eucommia ulmoides in the treatment of Parkinson's disease and provide reference for future research directions of Eucommia ulmoides in the treatment of Parkinson's disease.