Advances in peripheral nervous system regenerative therapeutic strategies: A biomaterials approach

Dalamagkas, Kyriakos; Tsintou, Magdalini; Seifalian, Alexander M.

doi:10.1016/j.msec.2016.04.048

Cited by 75 publications

(62 citation statements)

References 109 publications

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“…Also, a significant number of in vivo studies on collagen conduits showed good functional outcomes in nerve reconstructions in rat, cat, dog and primate models [113][114][115]. Researchers and surgeons have, however, raised their concern about these conduits due to its high cost, conduit stiffness, lack of flexibility and poor enhancement of nerve regeneration [116,117]. Also, collagen conduit application on major peripheral nerve injuries is limited to median and ulnar nerve repairs at the wrist and only observed as an alternative to the classic epineural suture repair [78].…”

Section: Collagenmentioning

confidence: 99%

“…As fibrin glue, it is widely used in sutures, thanks to its semisolid structure that enhances haemostasis and integrity of the repair and also due to its angiogenesis, chemotaxis, leucocytosis and macrophage proliferation stimulation [119,120]. When used in a conduit, fibrin has shown to promote axon regeneration and functional recovery in small gaps [116,121,122]. Rafijah and colleagues [123] have reported the use of collagen conduits filled with fibrin glue in 10-mm rat sciatic nerve defect.…”

Section: Fibrinmentioning

confidence: 99%

“…Their nerve conduits are resolvable polyester with the advantage of being transparent and with less acidic degradation product that therefore causes less toxic reaction [60, 84,116,152].…”

Section: Poly (D L Lactide-co-ε-caprolactone)mentioning

confidence: 99%

“…Polyhydroxybutyrate (PHB) is a polyester polymer, also used in sutures and wound dressings [116,169]. PHB has a long degradation time, up to 24-30 months [116,169].…”

Section: Polyhydroxybutyratementioning

confidence: 99%

“…PHB has a long degradation time, up to 24-30 months [116,169]. It has been reported that PHB has a neuroprotective effect and can help axon regeneration [170,171].…”

Section: Polyhydroxybutyratementioning

confidence: 99%

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Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Collagenmentioning

confidence: 99%

Section: Fibrinmentioning

confidence: 99%

“…Their nerve conduits are resolvable polyester with the advantage of being transparent and with less acidic degradation product that therefore causes less toxic reaction [60, 84,116,152].…”

Section: Poly (D L Lactide-co-ε-caprolactone)mentioning

confidence: 99%

“…Polyhydroxybutyrate (PHB) is a polyester polymer, also used in sutures and wound dressings [116,169]. PHB has a long degradation time, up to 24-30 months [116,169].…”

Section: Polyhydroxybutyratementioning

confidence: 99%

“…PHB has a long degradation time, up to 24-30 months [116,169]. It has been reported that PHB has a neuroprotective effect and can help axon regeneration [170,171].…”

Section: Polyhydroxybutyratementioning

confidence: 99%

See 3 more Smart Citations

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Bredigite‐Based Bioactive Nerve Guidance Conduit for Pro‐Healing Macrophage Polarization and Peripheral Nerve Regeneration

Xuan,

Li,

Yin

et al. 2023

Adv Healthcare Materials

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Structural and functional healing of peripheral nerves damaged by trauma or chronic disease remain major clinical challenges, requiring the development of an effective nerve guidance conduit (NGC). The present study investigated a NGC fabrication strategy based on bredigite (BRT, Ca7MgSi4O16) bioceramic for the treatment of peripheral nerve injury. Here, BRT bioceramic showed good biocompatibility and sustainable release of Ca2+, Mg2+ and Si4+ ions. Both BRT extracts and BRT‐incorporating electrospun membranes promoted the proliferation and myelination potential of RSC96 cells, as well as accelerated vascular formation by human umbilical vein endothelial cells. Notably, BRT facilitated RAW 264.7 cell polarization to the pro‐healing phenotype under LPS‐induced inflammatory stimulation. More importantly, the macrophages activated by BRT in turn promoted RSC96 cell migration and remyelination. In a rat sciatic nerve defect model, improved electrophysiological performance and alleviated gastrocnemius muscle atrophy were observed at 12 weeks post‐implantation. Further experiments verified that BRT‐loaded NGC facilitated axonal regrowth and revascularization with high M2‐like macrophage infiltration. These findings support the beneficial effects of BRT for creating a pro‐healing immune microenvironment and orchestrating multicellular processes associated with functional nerve regeneration, indicating the potential of rationally engineered bioceramics as safe, effective and economical materials for peripheral nerve repair.This article is protected by copyright. All rights reserved

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Functional Polymer‐Based Nerve Guide Conduits to Promote Peripheral Nerve Regeneration

Zhang

et al. 2020

Adv Materials Inter

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Bridging critical‐sized defects in peripheral nerves to achieve functional recovery is a challenge for orthopedic and hand surgeons. Inadequate regeneration of peripheral nerve axons often results in long‐term partial or total sensory and/or motor impairment. Currently, the best treatment available for long‐gap peripheral nerve regeneration is autologous nerve transplantation, while the successful implementation of this approach requires for secondary surgery and donor nerves. The nerve guide conduit (NGC) serves as an alternative to autograft of nerve, as it connects the proximal and distal ends of nerve defects and provides physical and biochemical guidances for axon regeneration. Functionalized NGCs enhance nerve regeneration by providing neuroprotection, antioxidation, vascular regeneration enhancement, and immune regulatory effects. In this review, the authors summarize the latest advances in functional polymer‐based NGCs for peripheral nerve regeneration and present the perspectives on the development of peripheral NGCs for potential clinical applications.

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Advances in peripheral nervous system regenerative therapeutic strategies: A biomaterials approach

Cited by 75 publications

References 109 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Bredigite‐Based Bioactive Nerve Guidance Conduit for Pro‐Healing Macrophage Polarization and Peripheral Nerve Regeneration

Functional Polymer‐Based Nerve Guide Conduits to Promote Peripheral Nerve Regeneration

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