Advances in Palladium-Catalyzed Carboxylation Reactions

Abstract

In this short review, we highlight the advancements in the field of palladium-catalyzed carbon dioxide utilization for the synthesis of high value added organic molecules. The review is structured on the basis of the kind of substrate undergoing the Pd-catalyzed carboxylation process. Accordingly, after the introductory section, the main sections of the review will illustrate Pd-catalyzed carboxylation of olefinic substrates, acetylenic substrates, and other substrates (aryl halides and triflates).

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

“…Oxidative carbonylation with PdI 2 (1 mol %)/KI(100 mol %) catalytic system gives 2-(4-acylfuran-2-yl) acetamides in fair to good yields (54-81 %). [38] They were the first to report the 2-(4-acylfuran-2-yl) acetamide as a product of carbonylation. The mechanistic pathway involving C sp À H activation of the substrate by oxidative monoaminocarbonylation leads to the formation of 2-ynamide intermediates.…”

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis. [35][36][37][38][39][40] Several authors have recently reviewed the cyclo-carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members. [41][42][43][44][45][46][47][48][49][50] This section explained the synthesis of α, βalkynyl ketones, coumarin, 2-quinolone, indol derivative, furane derivative, and chromenone heterocyclic compound from homogenous palladium-catalyzed carbonylation reaction.…”

“…For 15 h, they preceded the reaction with 2‐propargyl‐1, 3‐dicarbonyl compounds, CO, and NR 2 H at 100 °C. Oxidative carbonylation with PdI 2 (1 mol %)/KI(100 mol %) catalytic system gives 2‐(4‐acylfuran‐2‐yl) acetamides in fair to good yields (54–81 %) [38] . They were the first to report the 2‐(4‐acylfuran‐2‐yl) acetamide as a product of carbonylation.…”

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis [35–40] . Several authors have recently reviewed the cyclo‐carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members [41–50] .…”