Advances in Ocular Drug Delivery

Rawas‐Qalaji, Mutasem; Williams, C. L.

doi:10.3109/02713683.2011.652286

Cited by 71 publications

(46 citation statements)

References 30 publications

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“…Intravitreal injections have been considered the preferred route of drug delivery to the eye during the past 2 decades, and they are the most effective drug delivery method for the retina. [4][5][6][7] Compared with systemic administration, this method has the advantages of localizing the drug effect with higher drug concentrations in the vitreous and retina. It is commonly performed by injecting a drug suspension or solution into the vitreous cavity in the center of the eye via pars plana using a 30 G needle.…”

Section: Introductionmentioning

confidence: 99%

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

Xu¹,

Xu²,

Liu³

et al. 2016

IJN

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To visually trace the diffusion and biodistribution of amphiphilic cation micelles after vitreous injection, various triblock copolymers of monomethoxy poly(ethylene glycol)–poly(ε-caprolactone)–polyethylenimine were synthesized with different structures of hydrophilic and hydrophobic segments, followed by labeling with near-infrared fluorescent dye Cyanine5 or Cyanine7. The micellar size, polydispersity index, and surface charge were measured by dynamic light scattering. The diffusion was monitored using photoacoustic imaging in real time after intravitreal injections. Moreover, the labeled nanoparticle distribution in the posterior segment of the eye was imaged histologically by confocal microscopy. The results showed that the hydrophilic segment increased vitreous diffusion, while a positive charge on the particle surface hindered diffusion. In addition, the particles diffused through the retinal layers and were enriched in the retinal pigment epithelial layer. This work tried to study the diffusion rate via a simple method by using visible images, and then provided basic data for the development of intraocular drug carriers.

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Section: Introductionmentioning

confidence: 99%

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

Xu¹,

Xu²,

Liu³

et al. 2016

IJN

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“…[2][3][4][5][6] A biodegradable implant is a matrix containing a biodegradable polymer, typically constructed from a synthetic aliphatic polyester of the poly-a-hydroxy acid family, such as polylactic acid (PLA), poly[d,l-lactide-co-glycolide] (PLGA) or poly[d,llactide-co-e-caprolactone] (PLC). 4 All are proven vehicles for sustained drug release. 2,3 They have many advantages because they can be fabricated with various sizes, shapes, and thickness to modulate the amount and duration of drug release, tailoring to different ocular diseases and severities, since polyhydroxyesters are fabricated easily with predictable biodegradation kinetics.…”

mentioning

confidence: 99%

Optimization of Subconjunctival Biodegradable Microfilms for Sustained Drug Delivery to the Anterior Segment in a Small Animal Model

Liu

Peng

Lwin

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Liu YC, Peng Y, Lwin NC, Wong TT, Venkatraman SS, Mehta JS. Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model. Invest Ophthalmol Vis Sci. 2013;54:260754: -261554: . DOI: 10.1167 PURPOSE. We evaluated a biodegradable, sustained-release, prednisolone acetate (PA)-loaded poly[d,l-lactide-co-e-caprolactone] (PLC) drug delivery system on its biocompatibility, feasibility and release characteristics in vitro and in vivo.METHODS. Blank and 40% PA-loaded PLC microfilms with a diameter of 2 mm were fabricated, and the degradation and drug release profiles of the microfilms were characterized in vitro and in vivo. The microfilms were implanted into the subconjunctival space of Lewis rats (n ¼ 48). All eyes were assessed clinically using slit-lamp biomicroscopy, and graded with HackettMcDonald ocular scoring system and anterior segment optical coherence tomography. Histologic and immunohistochemical analyses were performed comparing blank and PAloaded microfilm groups. PA concentrations in the aqueous humor were determined by HPLC.RESULTS. Subconjunctivally-implanted PLC microfilms were able to deliver PA in a sustained manner over 3 months, with a steady rate of 0.002 mg/d in vivo. Eyes with either blank or PAloaded implanted microfilms showed a very minimal inflammatory response at the insertion sites and mild degree of collagen encapsulation around the microfilms, with significantly less CD11c cells at 2 and 4 weeks (P ¼ 0.001 and P ¼ 0.002), and collagen formation at 2 weeks (P ¼ 0.001) in the PA-loaded microfilm group. Anterior chamber PA levels were achieved, with concentrations at 76.7 6 5.9, 70.3 6 2.3, and 42.7 6 4.1 ng/mL at 2, 4, and 12 weeks, respectively.CONCLUSIONS. PA-loaded PLC microfilms display good biocompatibility, feasibility, and desirable sustained drug release profiles, and have the potential to exhibit antifibrotic and antiinflammatory effects. This device is applicable to use in small animal models of anterior segment inflammation.

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“…They also irritate the eye and produce temporary blurred vision after application, causing discomfort to the patient and leading to poor patient compliance. 30,31 The physiological barriers that limit the efficacy of eye drops also produce limitations for drugs delivered via subconjunctival and intravitreal injections. In addition, these methods can be more invasive and expensive.…”

Section: Current Treatment Options For Corneal Nvmentioning

confidence: 99%

Nanotechnology in Corneal Neovascularization Therapy—A Review

Gonzalez

Loza

Han

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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Nanotechnology is an up-and-coming branch of science that studies and designs materials with at least one dimension sized from 1-100 nm. These nanomaterials have unique functions at the cellular, atomic, and molecular levels.1 The term ''nanotechnology'' was first coined in 1974. 2 Since then, it has evolved dramatically and now consists of distinct and independent scientific fields. Nanotechnology is a highly studied topic of interest, as nanoparticles can be applied to various fields ranging from medicine and pharmacology, to chemistry and agriculture, to environmental science and consumer goods. 3 The rapidly evolving field of nanomedicine incorporates nanotechnology with medical applications, seeking to give rise to new diagnostic means, treatments, and tools. Over the past two decades, numerous studies that underscore the successful fusion of nanotechnology with novel medical applications have emerged. This has given rise to promising new therapies for a variety of diseases, especially cancer. It is becoming abundantly clear that nanotechnology has found a place in the medical field by providing new and more efficient ways to deliver treatment. Ophthalmology can also stand to benefit significantly from the advances in nanotechnology research. As it relates to the eye, research in the nanomedicine field has been particularly focused on developing various treatments to prevent and/or reduce corneal neovascularization among other ophthalmologic disorders. This review article aims to provide an overview of corneal neovascularization, currently available treatments, and where nanotechnology comes into play.

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Advances in Ocular Drug Delivery

Cited by 71 publications

References 30 publications

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

Optimization of Subconjunctival Biodegradable Microfilms for Sustained Drug Delivery to the Anterior Segment in a Small Animal Model

Nanotechnology in Corneal Neovascularization Therapy—A Review

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