Advances in Nucleoside and Nucleotide Analogues in Tackling Human Immunodeficiency Virus and Hepatitis Virus Infections

Ramesh, Deepthi; Vijayakumar, Balaji Gowrivel; Kannan, Tharanikkarasu

doi:10.1002/cmdc.202000849

Cited by 33 publications

(21 citation statements)

References 108 publications

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“…According to the literature, several infections which are caused by viruses such as human immunodeficiency virus (HIV), hepatitis V virus (HBV) or hepatitis C virus (HCV) can be treated with nucleoside analogues [ 42 , 43 ]. These agents are considered as safe and well tolerated since they are only used by the viral polymerase and not by human polymerase in DNA replication.…”

Section: Discussionmentioning

confidence: 99%

Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Daikopoulou¹,

Apostolou²,

Mourati³

et al. 2021

Molecules

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Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Daikopoulou¹,

Apostolou²,

Mourati³

et al. 2021

Molecules

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“…N ‐glycosides including Nucleosides, glycoproteins and glycopeptides are essential components of DNA/RNA, enzymes and antibodies in living systems [65a,b] . N ‐Heterocyclic glycosides also exhibit important physiological properties such as antiviral, anticancer, antibacterial and antifungal activities or inhibition against several glycosidases [65c] .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of 5‐MemberedN‐Heterocycles via Rhodium Catalysed Cascade Reactions

et al. 2022

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Five membered N-heterocycles are significant targets in organic synthesis because of their ubiquitous existence in bioactive natural products and pharmaceuticals. Over the past decade a compelling attractiveness has grown to develop rhodium complex catalysed efficient and atom-economic chemistry to access structurally diverse N-heterocyclic frameworks. This present review enlightens notable progresses and advances in synthesis of 5-membered N-heterocycles via rhodium catalysed cascade reactions (annulations, CÀ H/CÀ C activation, cycloaddition, rearrangement, cyclization, metathesis) from 2018-2021.[a] D.

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“…Carboplatin resembles cisplatin in terms of vomiting and nephrotoxicity [6,7]. Carboplatin primarily reacts with alkyl groups on nucleotides [8,9], which is necessary for DNA fragmentation [10,11], and simple adducts after restoration enzymes correct the error. Carboplatin and plasma protein [12] have no affinity for each other.…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of Carboplatin and Docetaxel Usi̇ng Rp-HPLC Wi̇th Pda Detector

DEVI¹,

RAMBABU²

2022

Int J App Pharm

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Objective: In the current investigation, to separated and validate the cancer healing drugs (Carboplatin and Docetaxel) through the HPLC (e-2695) instrument containing a PDA detector. Methods: A simple, selective, validated and well-defined stability that shows isocratic RP-HPLC methodology for the quantitative determination of Carboplatin and Docetaxel. The chromatographic strategy utilized Symmetry C18 column of dimensions 150x4.6 mm, 3.5 micron, using isocratic elution with a mobile phase of acetonitrile and 0.1% ortho phosphoric acid (40:60). A flow rate of 1 ml/min and a detector wavelength of 225 nm utilizing the PDA detector were given in the instrumental settings. Recovery, specificity, linearity, accuracy, robustness, ruggedness were determined as a part of method validation and the results were found to be within the acceptable range. Validation of the proposed method was carried out according to an international conference on harmonization (ICH) guidelines. Results: LOD and LOQ for the two active ingredients were established with respect to test concentration. The calibration charts plotted were linear with a regression coefficient of R2>0.999. Conclusion: The proposed method to be fast, simple, feasible and affordable in assay condition. During stability tests, it can be used for routine analysis of production samples and to verify the quality of drug samples during stability studies.

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Advances in Nucleoside and Nucleotide Analogues in Tackling Human Immunodeficiency Virus and Hepatitis Virus Infections

Cited by 33 publications

References 108 publications

Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Recent Advances in the Synthesis of 5‐MemberedN‐Heterocycles via Rhodium Catalysed Cascade Reactions

Rapid Determination of Carboplatin and Docetaxel Usi̇ng Rp-HPLC Wi̇th Pda Detector

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