Advances in Nanotoxicology: Towards Enhanced Environmental and Physiological Relevance and Molecular Mechanisms

Kahru, Anne; Mortimer, Monika

doi:10.3390/nano11040919

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Understanding the mechanism of action of nanoparticles in different organisms and in the environment remains a challenge to be overcome by researchers worldwide. Recent trends in nanotoxicology include incorporation of high-throughput screening approaches to establish structureactivity relationships using libraries of NPs with different properties and in vitro screening assays combined with computational analysis; omics-approaches, including metabolomics, proteomics, and transcriptomics, to discover molecular-level effects of NPs at low and sub-lethal concentrations; and method development to include sensitive toxicity assays for early detection of toxic effects [18][19][20][21].…”

Section: Resultsmentioning

confidence: 99%

Nanotoxicology: Scopus and Pubmed Data Mining and Bibliographic Map Comparative Analysis Using VOSviewer Software

Delfino¹,

Tebaldi²,

Souza³

et al. 2023

Anais Da 2ª Conferência Brasileira De Planejamento Experimental E Análise De Dados: ConBraPA 2022

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Nanotoxicology emerged from the need to understand the impact of nanomaterials on human and environmental health in a safe way. Currently, there are many literature data that can be processed using Data Science, including Data Mining Objective: Compare data obtained from Scopus Database (Elsevier) and PubMed in the period 2017-2022 to obtain bibliometric maps via VOSviewer Software. Methods: Search for articles with the term "nanotoxicology" in Scopus and Pubmed indexing sources and obtain articles in RIS format for processing via VOSViewer; reference the generation of VOSviewer clusters and nodes; Results: 1624 articles were obtained from the Scopus database and 1247 documents from the Pubmed database. The keywords with the most occurrences were "nanotoxicology", "nanoparticles", "human" and "animals. Conclusion:VOSviewer is a software that allows data collection and an integrative visualization of keywords and their occurrences.

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Section: Resultsmentioning

confidence: 99%

Nanotoxicology: Scopus and Pubmed Data Mining and Bibliographic Map Comparative Analysis Using VOSviewer Software

Delfino¹,

Tebaldi²,

Souza³

et al. 2023

Anais Da 2ª Conferência Brasileira De Planejamento Experimental E Análise De Dados: ConBraPA 2022

View full text Add to dashboard Cite

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Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid

Wang,

Liang,

Andrikopoulos

et al. 2024

Advanced Science

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Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of nanomaterials in cellular and organismal models, the active remediation of the adverse biological and environmental effects of nanomaterials remains largely unexplored. Inspired by recent developments in functional amyloids for biomedical and environmental engineering, this work shows their new utility as metallothionein mimics in the strategically important area of NanoEHS. Specifically, metal ions released from CuO and ZnO nanoparticles are sequestered through cysteine coordination and electrostatic interactions with beta‐lactoglobulin (bLg) amyloid, as revealed by inductively coupled plasma mass spectrometry and molecular dynamics simulations. The toxicity of the metal oxide nanoparticles is subsequently mitigated by functional amyloids, as validated by cell viability and apoptosis assays in vitro and murine survival and biomarker assays in vivo. As bLg amyloid fibrils can be readily produced from whey in large quantities at a low cost, the study offers a crucial strategy for remediating the biological and environmental footprints of transition metal oxide nanomaterials.

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“Challenges and toxicity assessment of inorganic nanomaterials in biomedical applications: Current status and future roadmaps”

Mahamuni-Badiger,

Dhanavade

2023

Journal of Drug Delivery Science and Technology

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Advances in Nanotoxicology: Towards Enhanced Environmental and Physiological Relevance and Molecular Mechanisms

Abstract: Nanotoxicology, a discipline transpired by the need to assess the human and environmental safety of nanoscale materials, has evolved over the past 15 years into a mature area of toxicology [...]

Cited by 3 publications

References 15 publications

Nanotoxicology: Scopus and Pubmed Data Mining and Bibliographic Map Comparative Analysis Using VOSviewer Software

Nanotoxicology: Scopus and Pubmed Data Mining and Bibliographic Map Comparative Analysis Using VOSviewer Software

Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid

“Challenges and toxicity assessment of inorganic nanomaterials in biomedical applications: Current status and future roadmaps”

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