Advances in Nanomedicine Design: Multidisciplinary Strategies for Unmet Medical Needs

Abstract

Globally, a rising burden of complex diseases takes a heavy toll on human lives and poses substantial clinical and economic challenges. This review covers nanomedicine and nanotechnology-enabled advanced drug delivery systems (DDS) designed to address various unmet medical needs. Key nanomedicine and DDSs, currently employed in the clinic to tackle some of these diseases, are discussed focusing on their versatility in diagnostics, anticancer therapy, and diabetes management. Firsthand experiences from our own laboratory and the work of others are presented to provide insights into strategies to design and optimize nanomedicine-and nanotechnology-enabled DDS for enhancing therapeutic outcomes. Computational analysis is also briefly reviewed as a technology for rational design of controlled release DDS. Further explorations of DDS have illuminated the interplay of physiological barriers and their impact on DDS. It is demonstrated how such delivery systems can overcome these barriers for enhanced therapeutic efficacy and how new perspectives of next-generation DDS can be applied clinically.

A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells

“…As indicated by the key role lipid nanoparticles play in protecting the mRNA encoding the SARS-CoV-2 antigens used in COVID-19 vaccines [8,9], these applications have already reached clinical settings. Indeed, there are a wide array of applications of nanotechnology in biomedicine, from diagnostics [42,43] to drug and gene delivery [30]. Specifically, the use of nanosystems as drug-vectors improves drug bioavailability, facilitates immune system evasion [44], and provides targeting properties [45].…”

A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

“…[40] In summary, a comprehensive and interdisciplinary platform for nanomedicine has been established. [41] The development of nanomedicine has the potential for revolutionary changes in the fields of life sciences and healthcare. This requires close collaboration between nanoscientists, medical researchers, engineers, and multidisciplinary professionals.…”

Biophysical investigation of liposome systems decorated with bioconjugated copolymers in the presence of amantadine

“…In recent years, an increasing number of contributions in the field of nanomedicine have focused on the usage of new biohybrid materials to formulate systems for improving drug administration. [1][2][3][4] In this regard, it has been documented that combinations of biocompatible polymers with bioactive molecules can enable synergistic properties for biomedical applications. [5][6][7][8][9] Fundamental knowledge related to biophysical properties and intermolecular interactions of cell membranes (or models) with other materials (e.g., smart polymers) is crucial for developing new drug delivery systems.…”

“…[5][6][7]17 In this context, the investigation of biohybrid systems that combine lipids, polymers, and bioactive moieties has led to considerable progress in the development of new therapeutic applications. 2,6,18,19 Furthermore, liposomes have been extensively used as model systems in the research of biomembranes and drug delivery approaches. [20][21][22] For example, combinations of liposomes with synthetic (co)polymers enable the self-assembly of vesicular nanostructures via diverse (but demanding) formulation processes, including microfluidic manufacturing.…”