Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin

Abstract

Diabetes is a major public health burden whose prevalence has been steadily increasing over the past decades. Glycated hemoglobin (HbA1c) is currently the gold standard for diagnostics and monitoring glycemic control in diabetes patients. HbA1c biosensors are often considered to be cost-effective alternatives for smaller testing laboratories or clinics unable to access other reference methods. Many of these sensors deploy nanomaterials as recognition elements, detection labels, and/or transducers for achieving sensitive and selective detection of HbA1c. Nanomaterials have emerged as important sensor components due to their excellent optical and electrical properties, tunable morphologies, and easy integration into multiple sensing platforms. In this review, we discuss the advantages of using nanomaterials to construct HbA1c sensors and various sensing strategies for HbA1c measurements. Key gaps between the current technologies with what is needed moving forward are also summarized.

Exploring Binding Affinities of Acetoacetate in Acrylamide-Based Polymers (Pam) for Molecularly Imprinted Polymers (Mips): A Molecular Docking and Molecular Dynamics Study

“…MIPs can be designed to recognize specific diabetes-related biomarkers, such as glycosylated hemoglobin (HbA1c) or other indicators of diabetes complications [14]. MIP-based biosensors can detect and quantify these biomarkers in biological samples, aiding in disease diagnosis, monitoring, and management [15].…”

Advances and perspectives of nanozymes in respiratory diseases

“…[15][16][17] Nanomaterialbased biosensors are considered reliable portable tools for analyte detection of respiratory disease, including biomolecules, antigens, drugs, viruses, bacteria, and others. [18][19][20][21] Therefore, researchers are constantly working to improve nanomaterialbased biosensors' active surface area, electrochemical activity, conductivity, and optical performance. On the other side, the exploration of nanomaterials permits the creation of an entirely new class of antioxidants and makes substantial advancements…”

Next Generation Non-Invasive Biomarker Testing in Saliva: The Organic Electrolyte Gated Field Effect Transistor Aptasensor System

“…Highly active materials such as enzymes and reactive proteins are analyzed using photometric assays where biomolecules of interest can be observed through colour change, indicating the functional activity of the sample [229]. More inert materials such as hormones are analyzed through immunoassays [230].…”