Advances in multi-omics study of biomarkers of glycolipid metabolism disorder

Fang, Xuefeng; Miao, Runyu; Wei, Jiahua; Wu, Haoran; Tian, Jiaxing

doi:10.1016/j.csbj.2022.10.030

Cited by 38 publications

(23 citation statements)

References 170 publications

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“…In light of these data, we sought to determine whether FBT administration affects the activation of AhR signaling during its regulation of dyslipidemia, hepatic steatosis, and steatohepatitis by evaluating the expression of hepatic AhR and AhRtarget genes involved in lipid metabolism and inflammation. 59,60 As expected, in line with the alterations of key gut microbiota and AhR ligands, the expression of AhR and its target gene Cyp1a1, which could indicate the activation of AhR, were significantly upregulated by FBT administration in HFD-fed mice. Besides, FBT administration increased the expression of another AhR-targeted gene, Pemt, which catalyzes the methylation of PE into PC.…”

Section: Food and Function Papersupporting

confidence: 70%

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Liu,

Wang,

Liu

et al. 2023

Food Funct.

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Section: Food and Function Papersupporting

confidence: 70%

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Liu,

Wang,

Liu

et al. 2023

Food Funct.

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“…Among of lncRNAs, the TUG1 has shown to be involved in the regulation of several cellular behaviors and its dysregulation could resulted in a myriad of diseases, such as cancer, cardiovascular disease and diabetic complications [7,[22][23][24]. The expression level of TUG1 was signi cantly increased in various types of cancer [7,22].…”

Section: Discussionmentioning

confidence: 99%

Silencing lncRNA TUG1 inhibits osteo/odontogenic differentiation of human dental pulp stem cells through the Wnt/β-catenin signaling pathway

Sun,

Jiang,

et al. 2024

Preprint

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Background Human dental pulp stem cells (hDPSCs), a type of mesenchymal stem cells (MSCs), can be induced to various tissues under appropriate conditions. LncRNA TUG1 has been shown to exert promoting effect on osteogenic differentiation, while its role in osteo/odontogenic differentiation of hDPSCs remains unclear. This study aimed to investigate the role of TUG1 during osteo/odontogenic differentiation of hDPSCs. Materials and methods The hDPSCs were characterized and identified using flow cytometry and assessment of their multidirectional differentiation capabilities. TUG1 knockdown was achieved by lentivirus-mediated TUG1 short hairpin RNA (shRNA) and confirmed by qRT-PCR. The osteo/odontogenic ability was evaluated by alkaline phosphatase (ALP) staining, alizarin red S (ARS) staining, qRT-PCR, and western blot. Lithium chloride (LiCl) was used as an agonist of the Wnt/β-catenin signaling pathway. Results The hDPSCs were characterized by flow cytometry and multidirectional differentiation experiments successfully. The expression of TUG1 was upregulated during the process of the osteo/odontogenic differentiation of hDPSCs. Knockdown of TUG1 attenuated the osteo/odontogenic potential of hDPSCs and decreased the expression of DSPP, DMP-1, Runx2, OCN and OPN. Besides, silencing of TUG1 significantly reduced the levels of the Wnt/β-catenin pathway related marker proteins, Wnt3a and β-catenin, while activation of Wnt/β-catenin signaling by LiCl markedly reversed the inhibitory effect of TUG1 silencing on the osteo/odontogenic differentiation of hDPSCs. Conclusion Our results imply that TUG1 might function through the Wnt/β-catenin signaling pathway to promote the osteo/odontogenic differentiation of hDPSCs.

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“…This microbiome may be characteristic of the population due to dietary and hygiene acts of the host, but it also presents a composition that is almost specific to each individual. Recent studies have shown the importance of the individual’s microbiome in the origin and/or intensity of different metabolic disorders, such as liver cirrhosis and hepatocarcinomas [ 304 ], progression of neurodegenerative diseases [ 304 , 305 ], glycolipids metabolism disorders [ 306 ], obesity [ 307 ], myocardinal fibrosis and some cardiovascular diseases [ 308 ], arterial hypertension [ 307 ], among others. These are consequences of the so-called gut dysbiosis, or dysbacteriosis, caused by an imbalance in the composition of the microbiome, altering its metabolic activity as a whole [ 202 , 309 , 310 ].…”

Section: Microbiome and Faecal Transplant: The Futurementioning

confidence: 99%

Journey of the Probiotic Bacteria: Survival of the Fittest

et al. 2022

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This review aims to bring a more general view of the technological and biological challenges regarding production and use of probiotic bacteria in promoting human health. After a brief description of the current concepts, the challenges for the production at an industrial level are presented from the physiology of the central metabolism to the ability to face the main forms of stress in the industrial process. Once produced, these cells are processed to be commercialized in suspension or dried forms or added to food matrices. At this stage, the maintenance of cell viability and vitality is of paramount for the quality of the product. Powder products requires the development of strategies that ensure the integrity of components and cellular functions that allow complete recovery of cells at the time of consumption. Finally, once consumed, probiotic cells must face a very powerful set of physicochemical mechanisms within the body, which include enzymes, antibacterial molecules and sudden changes in pH. Understanding the action of these agents and the induction of cellular tolerance mechanisms is fundamental for the selection of increasingly efficient strains in order to survive from production to colonization of the intestinal tract and to promote the desired health benefits.

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Advances in multi-omics study of biomarkers of glycolipid metabolism disorder

Cited by 38 publications

References 170 publications

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Silencing lncRNA TUG1 inhibits osteo/odontogenic differentiation of human dental pulp stem cells through the Wnt/β-catenin signaling pathway

Journey of the Probiotic Bacteria: Survival of the Fittest

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