Advances in Mucin Biopolymer Research: Purification, Characterization, and Applications

Marczynski, Matthias; Winkeljann, Benjamin; Lieleg, Oliver

doi:10.1002/9783527818310.ch6

Cited by 10 publications

(7 citation statements)

References 164 publications

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“…Due to its location, it is highly susceptible to external environmental influences and requires complex and well-developed defense mechanisms to maintain its integrity. Mucins are located in the epithelial layer, with secreted mucins having appeared early in the evolution of metazoans and formed transmembrane structures involved in the protection, repair, and survival of vertebrate epithelia [ 5 , 15 , 16 , 17 ]. The family of mucins to which MUC1 belongs is that of large, highly glycosylated proteins [ 7 ].…”

Section: The Structure Of Muc1mentioning

confidence: 99%

“…The family of mucins to which MUC1 belongs is that of large, highly glycosylated proteins [ 7 ]. There are three types of mucins: trans-membrane (e.g., MUC1, MUC4, and MUC16), secreted (gel-forming) (e.g., MUC2, MUC5AC, and MUC6), and soluble (non-gel-forming) (e.g., MUC7, MUC8, MUC9, and MUC20) [ 17 , 18 , 19 ]. MUC1, the best-characterized transmembrane mucin, has a variable number of highly glycosylated, 20-amino acid tandem repeats (VNTR), a sperm protein-enterokinase-agarin (SEA) domain (extracellular), a transmembrane domain, and a 72-amino acid cytoplasmic tail domain that extends up to 200–500 nm out of the cell surface ( Figure 1 A) [ 20 , 21 , 22 , 23 ].…”

Section: The Structure Of Muc1mentioning

confidence: 99%

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MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Chen

Zhu

Zhang

et al. 2021

IJMS

121

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The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

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Section: The Structure Of Muc1mentioning

confidence: 99%

Section: The Structure Of Muc1mentioning

confidence: 99%

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Chen

Zhu

Zhang

et al. 2021

IJMS

121

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“…The adhesion strategy used by hagfishes ( Myxine glutinosa ) is based on cross-linked networks made from mucin-like glycoproteins and protein filaments. Mucins are large glycoproteins that are ubiquitous in the animal kingdom, where they are involved in a broad range of functions such as providing anti-bacterial/anti-viral barriers, lubricity and tissue hydration [ 231 , 232 ]. The chemical structure of the mucin glycoproteins can be simply described as the protein core domain where serine and threonine residues are connected to branched oligosaccharides through O -glycoside bonds [ 233 ].…”

Section: Chemistry Of Biological Adhesives and Their Biomedical Applicationsmentioning

confidence: 99%

“…The individual qniumucins can then oligomerize and form a network. Differently from mammalian mucins, where oligomerization is established via cysteines [ 231 ], the content of cysteines in qniumucin is comparably low [ 242 ]. Based on NMR investigations, Uzawa et al.…”

Section: Chemistry Of Biological Adhesives and Their Biomedical Applicationsmentioning

confidence: 99%

Bio-based and bio-inspired adhesives from animals and plants for biomedical applications

Lutz

Kımna

Casini

et al. 2022

Materials Today Bio

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With the “many-headed” slime mold Physarum polycelphalum having been voted the unicellular organism of the year 2021 by the German Society of Protozoology, we are reminded that a large part of nature's huge variety of life forms is easily overlooked – both by the general public and researchers alike. Indeed, whereas several animals such as mussels or spiders have already inspired many scientists to create novel materials with glue-like properties, there is much more to discover in the flora and fauna. Here, we provide an overview of naturally occurring slimy substances with adhesive properties and categorize them in terms of the main chemical motifs that convey their stickiness, i.e. , carbohydrate-, protein-, and glycoprotein-based biological glues. Furthermore, we highlight selected recent developments in the area of material design and functionalization that aim at making use of such biological compounds for novel applications in medicine – either by conjugating adhesive motifs found in nature to biological or synthetic macromolecules or by synthetically creating (multi-)functional materials, which combine adhesive properties with additional, problem-specific (and sometimes tunable) features.

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“…Although we are able to extract and purify different types of mucins from animals, humans, or other organisms, [95] development and testing of bacterial and plant-based extracellular polymeric substances are still important and desirable since biological mucin coated surfaces, particularly developed for implants, do not always provide a broad spectrum biofilm growth prevention, limited by the bound glycans. [96] Snail mucins may overcome this problem as they are becoming increasingly popular.…”

Section: Snail Produced Mucin Proteinsmentioning

confidence: 99%

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Bayer

2022

Adv Materials Inter

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Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways. Mucin is the key polymeric compound that is known as a family of high molecular weight, heavily glycosylated proteins in epithelial tissues. Mucoadhesion can occur in many different ways such as receptor specific and charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers that replicate its beneficial traits can prevent biofilm formation and biofouling not only in biotechnology but also in membrane technologies. This review addresses the latest understandings related to mucin's role in wet adhesion considering different physiological conditions and shows how this translates into interfacial polymer adhesion. Advances in mucoadhesion measurement techniques including the rheological aspects of polymer–mucin adhesive interactions are presented. Specific mucoadhesive systems are discussed such as hydrogel mucoadhesion, catechol/dopamine functionalization, and polymeric nanoparticles. This overview may expand the current understanding of mucoadhesion between soft materials but also contributes to elastocapillary phenomena in soft materials design and applications such as new membranes, drugs, pharmaceutical devices, and lubricated surfaces.

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Advances in Mucin Biopolymer Research: Purification, Characterization, and Applications

Cited by 10 publications

References 164 publications

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Bio-based and bio-inspired adhesives from animals and plants for biomedical applications

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

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