Advances in microbial metabolic engineering for the production of butanol isomers (isobutanol and 1-butanol) from a various biomass

Hussain, Asif; Shahbaz, Umar; Khan, Salman; Basharat, Samra; Ahmad, Khalil; Khan, F. Z.; Xia, Xiaole

doi:10.1007/s12155-022-10410-8

Cited by 7 publications

(6 citation statements)

References 83 publications

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“…Aldehyde dehydrogenase is used in the Ehrlich pathway, however, to transform 2ketoisovalerate, a by-product of valine biosynthesis, into isobutanol. In essence, the Ehrlich route in S. cerevisiae uses 2-ketoisovalerate as a precursor molecule to produce isobutanol [39,40]. Despite the possibility of producing 1butanol using S. cerevisiae, little has been done to completely understand its cellular metabolism.…”

Section: Metabolic Engineering Of Scerevisiae For Bio Butanol Productionmentioning

confidence: 99%

“…Similar to E. coli and Clostridium species, S. cerevisiae may synthesize butanol. various metabolic approaches have been applied to S. cerevisiae for production of two main isomers of butanol such as Iso-butanol and 1-butanol [40].…”

Section: Metabolic Engineering Of Scerevisiae For Bio Butanol Productionmentioning

confidence: 99%

“…Since many different biomolecules require acetoacetyl-CoA as a precursor, foreign genes must be expressed to create heterologous enzymes that can convert acetoacetyl-CoA into 1-butanol. [40]. In their first attempt, Steen and his team successfully produced 1-butanol in S. cerevisiae by expressing isoenzymes from multiple sources to construct the 1butanol pathway.…”

Section: Biological Production Of 1-butanol By Engineered Scerevisiaementioning

confidence: 99%

See 2 more Smart Citations

Metabolic engineering of Saccharomyces cerevisiae for ethanol and butanol biofuel production

Khan¹,

Hussain²,

Hussain³

et al. 2023

IJEAB

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The production of biofuels through biological processes has garnered increasing attention due to their potential benefits over conventional fuels, including lower greenhouse gas emissions, higher energy output, and reduced-price fluctuations. However, the metabolic processes of primitive microorganisms used in biofuel production are not compatible with those of fossil fuels. To address this, scholars have employed metabolic engineering techniques to modify the metabolisms of various microorganisms, including S. cerevisiae, for enhanced biofuel production. Specifically, overexpression of enzymes involved in bioethanol and biobutanol production, knockouts of competing pathways, improvements in carbon flux and tolerance have been applied to maximize the potential of S. cerevisiae for bioethanol and biobutanol production. This review focuses on the current state of metabolic engineering of S. cerevisiae for the production of bioethanol from lignocellulose and biobutanol from all kind of substrates, along with the potential use of cell surface technology in this field.

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Section: Metabolic Engineering Of Scerevisiae For Bio Butanol Productionmentioning

confidence: 99%

Section: Metabolic Engineering Of Scerevisiae For Bio Butanol Productionmentioning

confidence: 99%

Section: Biological Production Of 1-butanol By Engineered Scerevisiaementioning

confidence: 99%

See 1 more Smart Citation

Metabolic engineering of Saccharomyces cerevisiae for ethanol and butanol biofuel production

Khan¹,

Hussain²,

Hussain³

et al. 2023

IJEAB

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…26 Microbial engineering has been extensively applied to enhance isobutanol production and increase the yields and titers obtained by different microorganisms, such as S. cerevisiae, [27][28][29][30] Escherichia coli, [31][32][33] and many others. [34][35][36][37][38][39][40][41][42][43] Different feedstocks have been used to produce isobutanol using these microorganisms. Atsumi et al engineered E. coli bacteria to produce 22 g L −1 of isobutanol from glucose.…”

Section: Introductionmentioning

confidence: 99%