Advances in microbial lignin degradation and its applications

Kamimura, Naofumi; Sakamoto, Shingo; Mitsuda, Nobutaka; Masai, Eiji; Kajita, Shinya

doi:10.1016/j.copbio.2018.11.011

Cited by 148 publications

(73 citation statements)

References 60 publications

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“…Recently, the production of value-added chemicals from lignin through a combination of the chemical depolymerization of lignin and subsequent microbial conversion of the resulting low-molecular-weight aromatic compounds, known as ‘biological funneling’, has attracted considerable attention 20,21 . In nature, the biological degradation of lignin is thought to progress mainly via depolymerization by fungi and subsequent mineralization by bacteria of the resulting low-molecular-weight aromatic compounds 22 . Therefore, the elucidation of microbial lignin catabolism systems is extremely important not only for their application to microbial conversion of lignin into value-added chemicals but also for understanding the carbon cycle on Earth.…”

Section: Introductionmentioning

confidence: 99%

A TonB-dependent receptor constitutes the outer membrane transport system for a lignin-derived aromatic compound

et al. 2019

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TonB-dependent receptors (TBDRs) mediate substrate-specific transport across the outer membrane, utilizing energy derived from the proton motive force transmitted from the TonB −ExbB−ExbD complex located in the inner membrane (TonB system). Although a number of TonB systems involved in the uptake of siderophores, vitamin B12 and saccharides have been identified, their involvement in the uptake and catabolism of aromatic compounds was previously unknown. Here, we show that the outer membrane transport of a biphenyl compound derived from lignin is mediated by the TonB system in a Gram-negative bacterium capable of degrading lignin-derived aromatic compounds, Sphingobium sp. strain SYK-6. Furthermore, we found that overexpression of the corresponding TBDR gene enhanced the uptake of this biphenyl compound, contributing to the improved rate of platform chemical production. Our results will provide an important basis for establishing engineered strains optimized for use in lignin valorisation.

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Section: Introductionmentioning

confidence: 99%

A TonB-dependent receptor constitutes the outer membrane transport system for a lignin-derived aromatic compound

et al. 2019

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“…The advantages and limitations of the employment of enzymes in lignin degradation were recently reviewed. [82][83][84][85] Another biofuel that can be obtained from biomass is biodiesel. This term refers to a mix of fatty acid alkyl esters (FAAEs) that can be produced from vegetable oil (triglycerides) through a trans-esterification process.…”

Section: Treatment Of Lignocellulosic Biomassesmentioning

confidence: 99%

Biocatalysis explained: from pharmaceutical to bulk chemical production

et al. 2019

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“…Bacterial anoxic depolymerization techniques need further development to valorize lignin, but exact mechanisms remain largely undefined (2–4). Known enzymes include glutathione S -transferases (GSTs) in the β-etherase system (5–8); however, isolation and characterization of anaerobic lignin-degrading bacteria will help advance understanding of and discover new mechanisms.…”

Section: Announcementmentioning

confidence: 99%