Advances in micro/nanodrug delivery systems for the treatment of Helicobacter pylori infection: From diagnosis to eradication

Bu, Fan; Song, Xinyu; Zhao, Xinbo; Wang, Ruihuan; Xie, Yidan; Yu, Liangmin; Yan, Xuefeng

doi:10.1016/j.apmt.2024.102138

Cited by 1 publication

(1 citation statement)

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“…For example, ergosterol has antifungal properties demonstrated against filamentous fungi such as Aspergillus flavus, Penicillium digitatum, among others [159]. In fact, Li et al [176] showed that ergosterol inhibits the growth of Helicobacter pylori, the main etiological agent associated with chronic gastritis and duodenal ulcers [177]. Ergosterol also affects the growth of Trypanosoma cruzi, the etiological agent that causes Chagas disease, as ergosterol permeabilizes the plasma and mitochondrial membranes, causing the death of the parasite.…”

Section: Sterols From Mushroomsmentioning

confidence: 99%

Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

Martinez-Burgos,

Montes Montes,

Pozzan

et al. 2024

Fermentation

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It is widely known that mushrooms present several properties with applications in the medicinal and pharmaceutical sectors, including antimicrobial, immunomodulatory, antioxidant, hypotensive, neuroprotective, and anti-inflammatory activities. This article aims to review examples of the bioactive metabolites responsible for those activities, such as polysaccharides, phenols and polyphenols, terpenes, peptides, alkaloids, and steroids, which are produced by several relevant mushroom species. It also discusses their production through solid-state fermentation and submerged fermentation, as well as the processes of obtention of mushroom bioactive extracts and considerations on their stability aiming industrial applications. In addition, the article examines the patent landscape surrounding mushroom-derived bioactives, shedding light on the intellectual property history and innovations driving this field forward. Examples of recently deposited patents in the field are highlighted, as well as the main depositors. China and the United States are the major depositor countries in this field (52% and 35% of patents, respectively), and the principal compounds on the patents are polysaccharides and alkaloids. The article also provides insights into the current market landscape, showcasing mushroom-derived products in the pharmaceutical field available to consumers. From dietary supplements to skincare formulations, the market offerings reflect the growing interest in harnessing the health benefits of mushroom bioactives.

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Section: Sterols From Mushroomsmentioning

confidence: 99%