Advances in metal-induced oxidative stress and human disease

Jomová, Klaudia; Valko, Marián

doi:10.1016/j.tox.2011.03.001

Cited by 2,601 publications

(1,708 citation statements)

References 255 publications

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“…GSH has a critical role in cell defense against oxidizing agents [43], acting as a reducing equivalent (H + + e -) donor. Low GSH levels are associated with oxidative stress, for which they are a good marker [44]. One method used to determine GSH levels in living cells is based on the GSH-sensitive probe mCB.…”

Section: In Vitro Dmsa-mnp Cytotoxicitymentioning

confidence: 99%

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

117

106

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Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribution, degradation and toxicity. We studied DMSA-coated magnetic nanoparticles effects in vitro on NCTC 1469 nonparenchymal hepatocytes, and analyzed their biodistribution and biotransformation in vivo in C57BL/6 mice. Our results indicate that DMSA-coated magnetic nanoparticles have little effect on cell viability, oxidative stress, cell cycle or apoptosis on NCTC 1469 cells in vitro. In vivo distribution and transformation was studied by alternating current magnetic susceptibility measurements, a technique that permits distinction of MNP from other iron species. Our results show that DMSA-coated MNP accumulate in spleen, liver and lung tissues for extended periods of time, in which nanoparticles undergo a process of conversion from superparamagnetic iron oxide nanoparticles to other nonsuperparamagnetic iron forms, with no significant signs of toxicity.

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Section: In Vitro Dmsa-mnp Cytotoxicitymentioning

confidence: 99%

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

117

106

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“…For example, the reducing ability of Cu + is critical for the activities of Cu-dependent enzymes like Cu/Zn superoxide dismutase (SOD), cytochrome oxidase and laccase [3]. On the other hand, high concentrations of Cu are toxic due to Fenton chemistry, by which Cu can generate harmful reactive oxygen species such as hydroxyl radicals [4,5]. Cu also has a high affinity to displace other metals from their cognate proteins leading to protein inactivation [2,6].…”

Section: Introductionmentioning

confidence: 99%

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

et al. 2018

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The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the second most frequent Aspergillus pathogen after A. fumigatus infecting immunosuppressed patients. In many human fungal pathogens including A. fumigatus, the ability to defend from toxic levels of copper (Cu) is essential in pathogenesis. In A. fumigatus, the Cu-fist DNA binding protein, AceA, and the Cu ATPase transporter, CrpA, play critical roles in Cu defense. Here, we show that A. flavus tolerates higher concentrations of Cu than A. fumigatus and other Aspergillus spp. associated with the presence of two homologs of A. fumigatus CrpA termed CrpA and CrpB. Both crpA and crpB are transcriptionally induced by increasing Cu concentrations via AceA activity. Deletion of crpA or crpB alone did not alter high Cu tolerance, suggesting they are redundant. Deletion of both genes resulted in extreme Cu sensitivity that was greater than that following deletion of the regulatory transcription factor aceA. The ΔcrpAΔcrpB and ΔaceA strains were also sensitive to ROI stress. Compared to wild type, these mutants were impaired in the ability to colonize maize seed treated with Cu fungicide but showed no difference in virulence on non-treated seed. A mouse model of invasive aspergillosis showed ΔcrpAΔcrpB and to a lesser degree ΔaceA to be significantly reduced in virulence, following the greater sensitivity of ΔcrpAΔcrpB to Cu than ΔaceA.

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“…Under physiological conditions, the normal production of reactive oxygen species (ROS) is counteracted by antioxidant scavengers and enzymes, which include both enzymes and non-enzymatic scavengers (de Kok et al 2006 ;Garcon et al 2006 ;Sun et al 2008 ). However, under abnormal conditions, excessive levels of ROS exceed the detoxification capacity of the antioxidant defences, thereby causing a change in the redox status of the cell (Jomova and Valko 2011 ;Lonkar and Dedon 2011 ;Ziech et al 2011 ). Oxidative stress subsequently triggers a cascade of events closely associated with inflammation, which is believed to play a key role in the air pollution/PM-induced development and/or exacerbation of acute and/or chronic lung diseases (Dagher et al 2005' Lodovici and Bigagli 2011Oh et al 2011 ;Schwarze et al 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic response in human lung epithelial cells and ion characteristics of urban-air particles from Torino, a northern Italian city

Alessandria¹,

Schilirò²,

Degan³

et al. 2014

Environ Sci Pollut Res

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Advances in metal-induced oxidative stress and human disease

Cited by 2,601 publications

References 255 publications

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

Cytotoxic response in human lung epithelial cells and ion characteristics of urban-air particles from Torino, a northern Italian city

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