Advances in Metabolic Engineering of Plant Monoterpene Indole Alkaloids
Vonny Salim,
Sara-Alexis Jarecki,
Marshall Vick
et al.
Abstract:Monoterpene indole alkaloids (MIAs) encompass a diverse family of over 3000 plant natural products with a wide range of medical applications. Further utilizations of these compounds, however, are hampered due to low levels of abundance in their natural sources, causing difficult isolation and complex multi-steps in uneconomical chemical syntheses. Metabolic engineering of MIA biosynthesis in heterologous hosts is attractive, particularly for increasing the yield of natural products of interest and expanding th… Show more
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