Advances in Medical Nutrition Therapy: Parenteral Nutrition

Itzhaki, Moran Hellerman; Singer, Pierre

doi:10.3390/nu12030717

Cited by 34 publications

(20 citation statements)

References 77 publications

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“…Furthermore, although the effects of EN and PN on gut microbiota are not fully understood, 13 EN demonstrates a benefit to the microbiome compared with PN in animating a diverse microbiome and preventing pathological transformations 13,14 . Nevertheless, there is an overwhelming evidence supporting the safety and effectiveness of PN in providing nutrition therapy for a range of indications in distinct groups including patients who are critically ill, patients who were not critically ill but hospitalized, and home PN recipients 4,15–17 …”

Section: Introductionmentioning

confidence: 99%

Peptide‐based formula: Clinical applications and benefits

et al. 2023

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The use of enteral nutrition (EN) continues to increase given benefits. However, with this increase in use, it is also becoming evident that enteral feeding intolerance (EFI) is also quite prevalent, leading to the inability to meet nutrition needs in many patients. Given the wide variability in the EN population as well as the number of formulas available, there is not a clear consensus regarding the best approach to EFI management. One approach that is emerging to improve EN tolerance is the use of peptide-based formulas (PBFs). PBFs refer to enteral formulas containing proteins that have been enzymatically hydrolyzed to dipeptides and tripeptides. These hydrolyzed proteins are often combined with higher medium-chain triglyceride content to generate an enteral formula that is essentially easier to absorb and utilize. Emerging data demonstrate that the use of PBF in patients with EFI may improve clinical outcomes along with a corresponding reduction in healthcare utilization and potentially the cost of care. This review aims to navigate through key clinical applications and benefits of PBF and to discuss relevant data shared in the literature.

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Section: Introductionmentioning

confidence: 99%

Peptide‐based formula: Clinical applications and benefits

et al. 2023

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“…Enteral nutrition plays an important role in the recovery of inflammatory bowel disease and is often the first choice of nutritional therapy because it is non-invasive and can help to restore intestinal function (Luo J. et al, 2022). However, parenteral nutrition becomes the first choice when radiation enteritis is accompanied by intestinal obstruction or when fasting is required before surgery (Hellerman Itzhaki and Singer, 2020). Regardless of parenteral nutrition or enteral nutrition, the addition of certain nutrients to the nutrient solution may contribute to the recovery of the condition, for example, Glutamine can provide essential nutrition for the intestine, prevent intestinal mucosal atrophy and ameliorate intestinal immune function (Scolapio et al, 2002).…”

Section: Symptomatic Treatment Of Radiation Enteritismentioning

confidence: 99%

Pathogenesis and therapy of radiation enteritis with gut microbiota

et al. 2023

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Radiotherapy is widely used in clinic due to its good effect for cancer treatment. But radiotherapy of malignant tumors in the abdomen and pelvis is easy to cause radiation enteritis complications. Gastrointestinal tract contains numerous microbes, most of which are mutualistic relationship with the host. Abdominal radiation results in gut microbiota dysbiosis. Microbial therapy can directly target gut microbiota to reverse microbiota dysbiosis, hence relieving intestinal inflammation. In this review, we mainly summarized pathogenesis and novel therapy of the radiation-induced intestinal injury with gut microbiota dysbiosis and envision the opportunities and challenges of radiation enteritis therapy.

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“…The underlying mechanism could be attributed to GLP-2’s anti-apoptotic action along with its regenerative impact on Paneth cells and intestine stem cells [ 136 ]. While parenteral nutrition remains the life-saving standard for nutrient delivery in patients with intestinal failure, serious complications may develop such as liver and intestinal mucosal barrier injury, inflammation, and bacterial translocation [ 137 , 138 ]. To further understand the role of GLP-2 to ameliorate parenteral nutrition-associated gut injury, using a mouse model of parenteral nutrition, Deng et al, showed that GLP-2 significantly suppressed the expression of pro-inflammatory cytokines TNF-a and IL-6 in the ileum and reduced serum levels of D-lactic acids and LPS [ 132 ].…”

Section: Glp-1 and Glp-2 As Regulators Of Intestine Integrity And Inf...mentioning

confidence: 99%

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

Abdalqadir

Adeli

2022

Microorganisms

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The intestine represents the body’s largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine–microbiota–immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.

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Advances in Medical Nutrition Therapy: Parenteral Nutrition

Cited by 34 publications

References 77 publications

Peptide‐based formula: Clinical applications and benefits

Peptide‐based formula: Clinical applications and benefits

Pathogenesis and therapy of radiation enteritis with gut microbiota

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

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