Advances in Medical Imaging Applied to Bone Metastases

González-Sistal, Àngel; Sánchez, Alicia Baltasar; Carnero, Michel Herranz; Morell, Á. Ruibal

doi:10.5772/28519

Cited by 7 publications

(5 citation statements)

References 43 publications

(40 reference statements)

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“…MRI is a very sensitive technique for detecting bone marrow metastases even before the osseous infiltration occurs as well as for spinal cord compression [8]. Furthermore, MRI offers a way to visualize the lesions with good spatial and contrast resolution, and without using ionizing radiation [9].…”

Section: Diagnostic Imagingmentioning

confidence: 99%

Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup

et al. 2014

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Bone is the most common site of distant metastases in breast cancer that can cause severe and debilitating skeletal related events (SRE) including hypercalcemia of malignancy, pathologic fracture, spinal cord compression and the need for palliative radiation therapy or surgery to the bone. SRE are associated with substantial pain and morbidity leading to frequent hospitalization, impaired quality of life and poor prognosis. The past 25 years of research on the pathophysiology of bone metastases led to the development of highly effective treatment options to delay or prevent osseous metastases and SRE. Management of bone metastases has become an integral part of cancer treatment requiring expertise of multidisciplinary teams of medical and radiation oncologists, surgeons and radiologists in order to find an optimal treatment for each individual patient. A group of international breast cancer experts attended a Skeletal Care Academy Meeting in November 2012 in Istanbul and discussed current preventive measures and treatment options of SRE, which are summarized in this evidence-based consensus for qualified decision- making in clinical practice.

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Section: Diagnostic Imagingmentioning

confidence: 99%

Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup

et al. 2014

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“…An accurate assessment of the response of both pathologies to treatment requires the structural changes in the bone to be visualized. In this regard, each of the aforementioned imaging techniques has its pros and cons [ 12 – 15 ]. Nowadays, the baseline diagnosis evaluation to detect lytic bone lesions comprises conventional radiography too [ 6 , 9 , 10 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, each of the aforementioned imaging techniques has its pros and cons [ 12 – 15 ]. Nowadays, the baseline diagnosis evaluation to detect lytic bone lesions comprises conventional radiography too [ 6 , 9 , 10 , 15 ]. Early identification of direct anatomic visualization of the bone or tumor could lead to changes in patient management and quality of life.…”

Section: Discussionmentioning

confidence: 99%

A Quantitative Method for the Characterization of Lytic Metastases of the Bone from Radiographic Images

Sánchez

Sistal

2014

The Scientific World Journal

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The aim of our study was to assess the diagnostic usefulness of the gray level parameters to distinguish osteolytic lesions using radiological images. Materials and Methods. A retrospective study was carried out. A total of 76 skeletal radiographs of osteolytic metastases and 67 radiographs of multiple myeloma were used. The cases were classified into nonflat (MM1 and OL1) and flat bones (MM2 and OL2). These radiological images were analyzed by using a computerized method. The parameters calculated were mean, standard deviation, and coefficient of variation (MGL, SDGL, and CVGL) based on gray level histogram analysis of a region-of-interest. Diagnostic utility was quantified by measurement of parameters on osteolytic metastases and multiple myeloma, yielding quantification of area under the receiver operating characteristic (ROC) curve (AUC). Results. Flat bone groups (MM2 and OL2) showed significant differences in mean values of MGL (P = 0.048) and SDGL (P = 0.003). Their corresponding values of AUC were 0.758 for MGL and 0.883 for SDGL in flat bones. In nonflat bones these gray level parameters do not show diagnostic ability. Conclusion. The gray level parameters MGL and SDGL show a good discriminatory diagnostic ability to distinguish between multiple myeloma and lytic metastases in flat bones.

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“…These bone lesions can induce skeletal-related events (SREs) as further complications of the disease, which are experienced by a further 5.9% of the patients [ 6 ]. These SREs, like pathological fractures, nerve compression syndromes or hypercalcemia, reduce the quality of life of the patients [ 9 , 10 , 11 ] and contribute to a major part to the significantly increased mortality and morbidity [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…the patients [9][10][11] and contribute to a major part to the significantly increased mortality and morbidity [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

DOTA-ZOL: A Promising Tool in Diagnosis and Palliative Therapy of Bone Metastasis—Challenges and Critical Points in Implementation into Clinical Routine

et al. 2020

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The novel compound 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-ZOL (DOTA-conjugated zoledronic acid) is a promising candidate for the diagnosis and therapy of bone metastasis. The combination of the published methodology for this bisphosphonate with pharmaceutical and regulatory requirements turned out to be unexpectedly challenging. The scope of this work is the presentation and discussion of problems encountered during this process. Briefly, the radiolabelling process and purification, as well as the quality control published, did not meet the expectations. The constant effort setting up an automated radiolabelling procedure resulted in (a) an enhanced manual method using coated glass reactors, (b) a combination of three different reliable radio thin-layer chromatography (TLC) methods instead of the published and (c) a preliminary radio high-pressure liquid chromatography (HPLC) method for identification of the compound. Additionally, an automated radiolabelling process was developed, but it requires further improvement, e.g., in terms of a reactor vessel or purification of the crude product. The published purification method was found to be unsuitable for clinical routine, and an intense screening did not lead to a satisfactory result; here, more research is necessary. To sum up, implementation of DOTA-ZOL was possible but revealed a lot of critical points, of which not all could be resolved completely yet.

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Advances in Medical Imaging Applied to Bone Metastases

Cited by 7 publications

References 43 publications

Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup

Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup

A Quantitative Method for the Characterization of Lytic Metastases of the Bone from Radiographic Images

DOTA-ZOL: A Promising Tool in Diagnosis and Palliative Therapy of Bone Metastasis—Challenges and Critical Points in Implementation into Clinical Routine

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