Advances in Mechanics of Soft Materials: A Review of Large Deformation Behavior of Hydrogels

Liu, Zishun; Toh, William; Ng, Teng Yong

doi:10.1142/s1758825115300011

Cited by 204 publications

(59 citation statements)

References 224 publications

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“…Since Beebe et al introduced PH structures for autonomous flow control inside microfluidic structures in 2000 [101], their publication has been cited over 1000 times, and hydrogel-based actuator schemes are among the most widely published basic approaches. Several review papers address hydrogel-based actuators in the context of (1) general issues concerning possibilities and limitations [102], (2) their mechanical deformation behavior [103], and (3) their application in From [87], Ó2015 IEEE. Reproduced with permission Fig.…”

Section: Polymer Hydrogelsmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

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Microfluidic devices have not yet evolved into commercial off-the-shelf products. Although highly integrated microfluidic structures, also known as lab-on-a-chip (LOC) and micrototal-analysis-system (lTAS) devices, have consistently been predicted to revolutionize biomedical assays and chemical synthesis, they have not entered the market as expected. Studies have identified a lack of standardization and integration as the main obstacles to commercial breakthrough. Soft microfluidics, the utilization of a broad spectrum of soft materials (i.e., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market. Recent advances in polymer science developing novel stimulus-active soft-matter materials may further increase the popularity and spreading of soft microfluidics. Stimulus-active polymers and composite materials change shape or exert mechanical force on surrounding fluids in response to electric, magnetic, light, thermal, or water/solvent stimuli. Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness and ease of fabrication. This review gives an overview of available actuation concepts that are based on functional polymers and points out promising concepts and trends that may have the potential to promote the commercial success of microfluidics.

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Section: Polymer Hydrogelsmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

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“…The first microfluidic actuators realized with these materials were reported at the turn of the century 17 ; since then, numerous devices have been fabricated: pumps (coupled to membranes) [18][19][20][21][22][23] , reconfigurable systems 24 , drug delivery devices 25 , self-regulating systems 26 , gel-based electroactive 27 or photoactive valves 28 , and MEMS-coupled active mixers 29 . Despite multiple laboratory projects and twenty years of research, several bottlenecks restrict the technology from developing: mediocre spatial resolution, limited miniaturization capabilities, long time responses (usually more than 10 s), complexity in the fabrication process and poor control of the physicochemistry 30,31 . The last point is crucial because it raises concerns about the reliability of the technology 32,33 .…”

Section: Introductionmentioning

confidence: 99%

Microfluidic actuators based on temperature-responsive hydrogels

D'Eramo

Chollet

Leman³

et al. 2018

Microsyst Nanoeng

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The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive, but limitations, in terms of spatial resolution, speed, reliability and integration, have hindered its development during the past two decades. By patterning and grafting poly(N-isopropylacrylamide) PNIPAM hydrogel films on plane substrates with a 2 μm horizontal resolution and closing the system afterward, we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now. In this paper, we demonstrate, for the first time with this technology, devices with up to 7800 actuated micro-cages that sequester and release solutes, along with valves actuated individually with closing and opening switching times of 0.6 ± 0.1 and 0.25 ± 0.15 s, respectively. Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test (NAAT) for the Human Synaptojanin 1 gene, which is suspected to be involved in several neurodegenerative diseases such as Parkinson's disease. The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs, hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics, that are, pressure actuated polydimethylsiloxane (PDMS) valves and droplets.

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“…low density, low cost, easily tailored properties and large deformation recovery capacity . These novel properties have drawn increasing attention for utilizing SMPs in many potential applications, such as deployable structures, biomedical devices, smart textiles and self‐healing composite systems …”

Section: Introductionmentioning

confidence: 99%

A modified phase‐based constitutive model for shape memory polymers

Pan

Zhou

Zhang

2018

Polymer International

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Constitutive models used for predicting the thermomechanical behavior of shape memory polymers (SMPs) are critical for the development of SMP applications. Among the existing models, the phase transition concept attracts wide attention due to its good predictive capacity and great convenience. However, most of the present phase transition models for SMPs have limitations or deficiencies in considering the effect of temperature change rate on the thermomechanical behavior of SMPs. In this paper, based on the kinetics of phase transitions, we propose a constitutive model in which the temperature change rate is incorporated into the phase evolution function to consider the effect of the temperature change rate on the thermomechanical properties of SMPs. Then experimental data under different recovery conditions for two different types of SMP materials are used to validate the predictive capacity and versatility of the present model. The predicted results agree quite well with the experimental observations, which demonstrates that the present model is robust enough to predict the complex thermomechanical behavior for different SMPs. In addition, through experiments and model predictions, we find that the shape free recovery curves at different heating rates can be easily predicted by just moving a reference recovery curve along the horizontal direction by a distance whose value is calculated through the proposed equation. © 2018 Society of Chemical Industry

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Advances in Mechanics of Soft Materials: A Review of Large Deformation Behavior of Hydrogels

Cited by 204 publications

References 224 publications

Stimulus-active polymer actuators for next-generation microfluidic devices

Stimulus-active polymer actuators for next-generation microfluidic devices

Microfluidic actuators based on temperature-responsive hydrogels

A modified phase‐based constitutive model for shape memory polymers

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