Advances in materials-based therapeutic strategies against osteoporosis

Chen, Lei; Song, Jing-han; Li, Song; Zhu, Yi-na; Liu, M.; Wan, Mei‐chen; Zhao, Minshou; Tay, Franklin R.; Niu, Li Na

doi:10.1016/j.biomaterials.2023.122066

Cited by 35 publications

(22 citation statements)

References 192 publications

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“…Over the past two decades, attentions have been increasingly paid to engineering nanomaterials to deliver drugs and genes for biomedical applications especially for diagnostic and/or therapeutic purposes. − Nanomaterials derived from the viruses have attracted more interest due to their large surface area, excellent loading capacity, and good biocompatibility − The cowpea chlorotic mottle virus (CCMV) are natural nanobiomaterials with well-defined architecture formed by the controlled self-assembly of coat proteins and are tailorable for post-functionalization. − The outer surface of CCMV can be further functionalized with bioligands such as antigens, therapeutic peptides, and fluorescent molecules to extend its application in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Virus Nanoparticles Alleviates Osteoporosis via Targeting the Function of RANK-Specific Motifs

Cao

Shen

et al. 2023

ACS Appl. Mater. Interfaces

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Osteoporosis is a common skeletal disease characterized by excessive osteoclast-induced bone loss. RANKL/RANK signaling pathway is essential for osteoclastogenesis and is a key target for osteoporosis. However, regarding the fact that RANKL/RANK also functions beyond bone, the total block of RANKL/RANK will have unwanted impact on other organs. Our previous study revealed that mutation of RANK-specific motifs inhibited osteoclastogenesis without effects on other organs in mice. However, the instability and low cellular uptake efficiency limited the application of the therapeutic peptide originating from the amino acid sequence of RANKspecific motifs (RM). To this end, in this study, the peptide RM (SRPVQEQGGA (C to N terminal)) was chemically modified onto the surface of the plant virus-based nanoparticles cowpea chlorotic mottle virus (CCMV). Subsequent experiments showed that the novel virus nanoparticles RM-CCMV had excellent biocompatibility and stability, which ultimately facilitated its cellular uptake efficiency and improved its inhibitive effects on osteoclastogenesis. Moreover, RM-CCMV achieved bone enrichment and suppressed bone resorption by inhibiting osteoclastogenesis and improving the parameters of bone histomorphology in murine femurs. To be mentioned, the effective dose of CCMV conjugated RM was only 6.25% of free RM. In summary, these results have provided a promising therapeutic strategy for osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Functionalized Virus Nanoparticles Alleviates Osteoporosis via Targeting the Function of RANK-Specific Motifs

Cao

Shen

et al. 2023

ACS Appl. Mater. Interfaces

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“…Over the past few decades, nanomaterials, owing to the high surface area to volume ratio and outstanding physicochemical properties, have been applied to a wide variety of biomedical fields, including antibacterial, biomedical imaging, and drug delivery for the disorder of bone metabolism. [10][11][12] Various inorganic nanoparticles such as gold, silver, and platinum nanoparticles, which show a size-dependent manner, have been utilized in the aforementioned application. [13][14][15] It was notably found that Ag NPs were one of the most attractive nanomaterials in biomedicine due to their applications in antibacterial and therapy of bone-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesized Silver Nanoparticles Inhibit Osteoclastogenesis by Suppressing NF‐κB Signaling Pathways

Wu,

Cheng,

et al. 2023

Advanced Biology

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Osteoclasts overactivity plays a critical role in the progress of inflammatory bone loss. In addition, ROS can facilitate the formation and function of osteoclasts. Silver nanoparticles (Ag NPs) with ROS scavenging activity are potential candidates for inflammatory bone loss. In this regard, the biosynthetic Ag NPs with low toxicity and high stability by using Flos Sophorae Immaturus extract as the reducing and capping agents are reported. The inflammatory bone loss model is established by injecting LPS. Quantitative reverse transcription‐polymerase chain reaction and Western Blot are utilized to determine the expression level of target biomarkers related to osteoclast formation. Ag NPs can significantly reduce the number of TRAP‐positive (TRAP+) cells. In addition, Ag NPs down‐regulate the expression of biomarkers relevant to osteoclast formation. Interestingly, Ag NPs can effectively suppress osteoclast formation via down‐regulating ROS‐mediated phosphorylation of NF‐κB pathways. The in vivo study shows that Ag NPs can ameliorate bone density and decrease osteoclast number. Due to these benefits, the constructed Ag NPs can delay the progression of inflammatory bone loss. These findings suggest that Ag NPs are a potential therapeutic agent in the treatment of inflammatory bone loss.

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“…O steoporosis (OP) is a skeletal metabolic disease that presents with chronic trabecular bone loss leading to increased bone fragility and fractures. 1,2 OP affects over 200 million people worldwide, making it a significant public health problem. 3 Despite its low fatality rate, OP reduces quality of life and causes long-term complications in children, young adults, and elderly people.…”

mentioning

confidence: 99%

“…4,5 However, current OP treatments are limited due to side effects and complications that result from long-term administration. 2,6 There is thus an urgent need to explore more effective prevention measures and treatments for osteoporosis, and natural product drug discovery is one effective avenue.…”

mentioning

confidence: 99%

“…Osteoporosis (OP) is a skeletal metabolic disease that presents with chronic trabecular bone loss leading to increased bone fragility and fractures. , OP affects over 200 million people worldwide, making it a significant public health problem . Despite its low fatality rate, OP reduces quality of life and causes long-term complications in children, young adults, and elderly people. , However, current OP treatments are limited due to side effects and complications that result from long-term administration. , There is thus an urgent need to explore more effective prevention measures and treatments for osteoporosis, and natural product drug discovery is one effective avenue.…”

mentioning

confidence: 99%

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Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145

Wang,

Feng,

Huang

et al. 2024

J. Nat. Prod.

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One novel rearranged pimarane diterpenoid, pestanoid A (1), and two reported molecules, nodulisporenones A (2) and B (3), were discovered from Pestalotiopsis sp. NBUF145 fungus associated with a 62 m deep mesophotic (“twilight”) zone Chalinidae sponge. The structures of 1–3 were identified by spectrometry, spectroscopy, quantum-chemical calculations, and X-ray crystallography. Compounds 1 and 2 inhibited bone marrow monocyte osteoclastogenesis in vitro with the IC50 values 4.2 ± 0.2 μM and 3.0 ± 0.4 μM, respectively, without observed cytotoxicity. Both 1 and 2 suppressed the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by inhibiting the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation.

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Advances in materials-based therapeutic strategies against osteoporosis

Cited by 35 publications

References 192 publications

Functionalized Virus Nanoparticles Alleviates Osteoporosis via Targeting the Function of RANK-Specific Motifs

Functionalized Virus Nanoparticles Alleviates Osteoporosis via Targeting the Function of RANK-Specific Motifs

Biosynthesized Silver Nanoparticles Inhibit Osteoclastogenesis by Suppressing NF‐κB Signaling Pathways

Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145

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