Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
Maria Roxana Biricioiu,
Mirela Sarbu,
Raluca Ica
et al.
Abstract:Gangliosides are highly abundant in the human brain where they are involved in major biological events. In brain cancers, alterations of ganglioside pattern occur, some of which being correlated with the neoplastic transformation, while others with the tumor proliferation. Of all the techniques, mass spectrometry (MS) has proven to be one of the most effective in gangliosidomics, due to its ability to characterize heterogeneous mixtures and discover species with biomarker value. This review highlights the most… Show more
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