Advances in management of Guillain–Barré syndrome

Doets, Alex Y; Jacobs, Bart C.; Doorn, Pieter A. van

doi:10.1097/wco.0000000000000602

Cited by 26 publications

(22 citation statements)

References 60 publications

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“…Patients may benefit from steroids, although intravenous immunoglobulin or plasma exchange is often required. 5 Although this patient did present with ataxia and loss of lower reflexes, he did not have progressive distal to proximal spread of symptoms typical for GBS.…”

Section: Questions/discussion Points Partmentioning

confidence: 70%

Educational Case: Burkitt Lymphoma

Alexander

Wake

2019

Academic Pathology

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The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1

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Section: Questions/discussion Points Partmentioning

confidence: 70%

Educational Case: Burkitt Lymphoma

Alexander

Wake

2019

Academic Pathology

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“…The use of imaging studies such as peripheral nerve ultrasound and MRI are helpful diagnostic tools to diagnose inflammatory peripheral nerve roots [34].…”

Section: Diagnosis Of Guillain-barre Syndrome and Miller Fisher Variantmentioning

confidence: 99%

Guillain-Barre Syndrome and Miller Fisher Variant in Zika Virus Disease

Jadah¹

2021

Current Concepts in Zika Research

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Guillain-Barre syndrome (GBS) is a serious neurological disorder associated with a rapid progressive ascending muscle paralysis, and it is the most common neurological autoimmune disorder that affects the peripheral nervous system, which is usually triggered by viral or bacterial infection. GBS is rare in children and characterized by rapid progressive onset ascending muscle weakness associated with pain and sensory dysfunction. Miller Fisher syndrome (MFS), a variant of GBS, is rare in pediatric population which is typically manifested by ataxic gait, ophthalmoplegia, and areflexia since it is rare in children. It is vitally important to early diagnose this condition and to initiate early treatment to prevent further complications and long-term morbidity. Since the outbreak of Zika virus, the incidence of GBS has been increased. Zika virus associated with autoimmune anti-ganglioside antibodies trigger which lead to GBS development. Zika virus infection should be strongly considered in patients who present with classical signs of Miller Fisher syndrome, especially travelers and residents from endemic areas.

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“…should be considered. Since CSF may include normal levels of cells and proteins, especially at the onset of presentation, its utility is questionable and is most appropriate in cases of diagnostic doubt [6,11,[18][19][20]. Electroneuromyography (ENMG): Demonstrates evidence of demyelination, allowing to confirm or clarify the injured anatomical site.…”

Section: Complementary Examsmentioning

confidence: 99%

“…Plasma exchange is performed at 200-250mL/kg, four to six sessions over eight to ten days, while intravenous immunoglobulin is administered at a dose of 400mg /kg/day for five days [12,17]. Corticosteroid therapy is not recommended because it is not sufficient, although some studies have shown short-term therapeutic benefits when associated with intravenous human immunoglobulin [17,[19][20][21]. Pharmacological treatment of pain, which is a complaint in about two-thirds of cases, cannot be forgotten.…”

Section: Predictors Of Acute Respiratory Failure [17]mentioning

confidence: 99%

Guillain-Barre syndrome

Lacerda

Galvão

Ferreira

et al. 2019

GSC Biol. and Pharm. Sci.

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Guillain-Barre syndrome is the most common and most severe acute flaccid paralysis, usually preceded by an infection or immune stimulation. A literature review of the last five years in Pubmed, Scopus, Embase, and Web of Science databases was done. Data were collected from epidemiological studies using the keywords. Guillain-Barrè syndrome (GBS) is an acute, severe, and fulminant polyradiculoneuropathy. It has ascending muscle weakness, rapid evolution, the involvement of respiratory muscles with an evolution period of up to four weeks. It has the Classic and Variant forms of clinical presentation. Guillain-Barrè Syndrome is a rapidly progressive disease. The diagnosis is clinical but requires exams such as electroneuromyography and cerebrospinal fluid analysis, so that treatment can be started as soon as possible to improve prognosis and increase survival of affected patients.

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Advances in management of Guillain–Barré syndrome

Abstract: New diagnostic tools may help to have early and accurate diagnosis in difficult GBS cases. Increased knowledge on the pathophysiology of GBS forms the basis for development of new, targeted, and personalized treatments that hopefully improve outcome.

Cited by 26 publications

References 60 publications

Educational Case: Burkitt Lymphoma

Educational Case: Burkitt Lymphoma

Guillain-Barre Syndrome and Miller Fisher Variant in Zika Virus Disease

Guillain-Barre syndrome

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