Advances in macrophage and T cell metabolic reprogramming and immunotherapy in the tumor microenvironment
Hua Cheng,
Yongbin Zheng
Abstract:Macrophages and T cells in the tumor microenvironment (TME) play an important role in tumorigenesis and progression. However, TME is also characterized by metabolic reprogramming, which may affect macrophage and metabolic activity of T cells and promote tumor escape. Immunotherapy is an approach to fight tumors by stimulating the immune system in the host, but requires support and modulation of cellular metabolism. In this process, the metabolic roles of macrophages and T cells become increasingly important, a… Show more
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