Advances in local and systemic drug delivery systems for post-surgical cancer treatment

Aquib, Md; Juthi, Ajkia Zaman; Farooq, Muhammad Asim; Ali, Manasik Gumah; Janabi, Alhamzah Hasan Waheed; Bavi, Sneha; Banerjee, Parikshit; Bhosale, Raghunath B.; Bavi, Rohit; Wang, Bo

doi:10.1039/d0tb00987c

Cited by 30 publications

(20 citation statements)

References 108 publications

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“…Local drug delivery offers dramatically higher drug concentrations in tumor tissues, while reducing harmful side effects to healthy organs and minimizing local tumor relapse [ 2 ]. Locoregional cancer treatment relies on the implementation of drug delivery vehicles for cancerous lesions.…”

Section: Introductionmentioning

confidence: 99%

“…This strategy involves synthetic or natural polymer-based foams, wafers, fiber mats, and scaffolds. In this approach, mostly biodegradable matrices are proposed to avoid additional surgery for the removal of the biomaterial and to prevent a chronic immune response against foreign bodies [ 2 ]. Systemic drug delivery relies on nanomaterial-based DDSs, such as liposomes, micelles, dendrimers, and nanoparticles (NPs) that deliver therapeutic agents to cancer [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Florczak

Deptuch

Kucharczyk

et al. 2021

Cancers

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For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Florczak

Deptuch

Kucharczyk

et al. 2021

Cancers

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“…Targeted drug delivery has received much interest in recent years, particularly for cancer treatment where it has the potential to not only improve the effectiveness of chemotherapy but also to minimize side effects and complications caused by indiscriminate exposure of healthy regions [ 25 ]. Highly targeted local administration of drugs, such as via intratumoral injection, therefore, has been actively studied as a solution to overcome such limitations [ 26 , 27 ]. Although intratumoral injections of drugs are feasible for various cancers and target organs, lack of controllability of drug transport to the target site (e.g.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic optical fiber for bacteria manipulation—characterization and visualization of accumulation behavior under plasmo-thermal trapping

Kim

Yeatman

Thompson

2021

Biomed. Opt. Express

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In this article, we demonstrate a plasmo-thermal bacterial accumulation effect using a miniature plasmonic optical fiber. The combined action of far-field convection and a near-field trapping force (referred to as thermophoresis)—induced by highly localized plasmonic heating—enabled the large-area accumulation of Escherichia coli . The estimated thermophoretic trapping force agreed with previous reports, and we applied speckle imaging analysis to map the in-plane bacterial velocities over large areas. This is the first time that spatial mapping of bacterial velocities has been achieved in this setting. Thus, this analysis technique provides opportunities to better understand this phenomenon and to drive it towards in vivo applications.

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“…For patients with different types of solid tumors, the most commonly used first‐line clinical treatment is combination of surgery and chemotherapy. However, one of the main problems of chemotherapy is the extremely low bioavailability of anti‐tumor drugs and adverse side effects 4–6 . Many nano‐platforms such as micelles, liposomes, vesicles and nanoparticles have been designed to prevent drug deterioration while increasing effective drug concentration at lesion site 7–10 .…”

Section: Introductionmentioning

confidence: 99%

“…However, one of the main problems of chemotherapy is the extremely low bioavailability of anti-tumor drugs and adverse side effects. [4][5][6] Many nano-platforms such as micelles, liposomes, vesicles and nanoparticles have been designed to prevent drug deterioration while increasing effective drug concentration at lesion site. [7][8][9][10] Among them, micelles have attracted much interest due to their advantageous characteristics, including good stability in vivo, long circulation in the bloodstream, sustained and adjustable drug release performance.…”

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confidence: 99%

Biocompatibility, drug release, and anti‐tumor effect of pH‐sensitive micelles prepared from poly(2‐ethyl‐2‐oxazoline)‐poly(DL‐lactide) block copolymers

Wang

Zhang

Shen

et al. 2021

Polymers for Advanced Techs

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Various ratios PEOz-PDLLA diblock copolymers were synthesized through ringopening polymerization of DL-lactide initiated by monohydroxyl terminated poly (2-ethyl-2-oxazoline) (PEOz-OH). The chemical composition and molar mass of the resulting copolymers were determined by using NMR and GPC. Spherical micelles with a diameter from 104 to 136 nm were obtained via self-assembly of PEOz-PDLLA in water, as evidenced by TEM and DLS. The CMC of copolymers was well below 0.01 mg/mL, and showed a decreasing trend with increase of PDLLA block length. A two-step procedure was applied to encapsulate curcumin taken as a hydrophobic model drug. Copolymers with longer PDLLA block exhibit enhanced drug loading capacity. In vitro drug release was carried out in phosphate buffered saline (PBS) at physiological and slightly acidic pH values. A pH-sensitive biphasic drug release behavior was detected with an initial burst release followed by slower prolonged release. Lower pH or shorter PDLLA block length leads to higher drug release rate because of faster degradation of micelles. Hemo-and cytocompatibility studies illustrated the excellent biocompatibility of PEOz-PDLLA micelles. MTT assay showed a significant cytotoxicity of curcumin-loaded micelles against A549 lung cancer cells. Therefore, it can be inferred that PEOz-PDLLA block copolymers with outstanding biocompatibility, controllable drug loading performance, and prolonged drug release present a good potential as nano-carrier of hydrophobic drugs.

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Advances in local and systemic drug delivery systems for post-surgical cancer treatment

Abstract: Surgery is considered to be the favored approach for the treatment of most of the solid tumor malignancies. The quality of life among cancer patients has significantly improved due to...

Cited by 30 publications

References 108 publications

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Plasmonic optical fiber for bacteria manipulation—characterization and visualization of accumulation behavior under plasmo-thermal trapping

Biocompatibility, drug release, and anti‐tumor effect of pH‐sensitive micelles prepared from poly(2‐ethyl‐2‐oxazoline)‐poly(DL‐lactide) block copolymers

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