Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin

Sadri, Ali-Reza; Jeschke, Marc G.; Amini-Nik, Saeid

doi:10.1155/2016/7920897

Cited by 29 publications

(18 citation statements)

References 82 publications

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“…Telocytes have been implicated in regeneration (Gherghiceanu and Popescu, ), repair (Gherghiceanu and Popescu, ; Sadri et al, ; Akram et al, ), homeostasis (Cretoiu et al, ), intercellular signalling (Gherghiceanu and Popescu, ), and angiogenesis (Manole et al, ) in humans and animals. In future studies, we will use TEM to determine the ultrastructure of telocytes and culture telocytes in vitro to profile the genetic information of related extracellular vesicles and signalling proteins.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice

Tian

Cheng

et al. 2019

Cell Biology International

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Telocytes had been identified as a peculiar stromal cell type implicated in tissue homeostasis and the development and pathophysiology of diseases. Telocyte existed in most organs and tissues in humans and animals. However, few studies have examined telocytes in ApoE gene deficient mice. In our studies, we verified the existence, the morphology and immunohistochemical characteristics of telocytes in critical organs of the ApoE−/− mice. Male adult ApoE−/− mice were selected as an experimental model. Immunohistochemical bio‐markers, such as CD34, CD117, CD28, Vimentin and PDGFR‐α were utilized to determine the distribution and morphology of telocytes in the heart, liver and kidney. Telocyte expressed positively for CD34 and CD117, and partial telocyte and telopode expressed positively for PDGFR‐α in heart and liver, but negatively in kidney. Double immunofluorescence assays for CD28/Vimentin, CD34/CD117 and CD34/PDGFR‐α were used to demonstrate the biochemistry speciality of telocytes, respectively. The evidence of telocytes in the ApoE‐/‐ mice is the first step of our sturdy, which aims to demonstrate changes in telocytes in atherosclerosis in this animal model.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice

Tian

Cheng

et al. 2019

Cell Biology International

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“…The liver is a multifunctional and highly regenerative organ, playing an important role in human physiology . While resilient, the liver is susceptible to tissue damage and, therefore, degenerative diseases.…”

Section: The Livermentioning

confidence: 99%

Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine

Szkolnicka

Hay

2016

Stem Cells

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The liver is one of the major organs in the human body. Severe or prolonged exposure of the liver to different factors may cause life‐threatening disease, which necessitates donor organ transplantation. While orthotopic liver transplantation can be used to effectively treat liver failure, it is an invasive procedure, which is severely limited by organ donation. Therefore, alternative sources of liver support have been proposed and studied. This includes the use of pluripotent stem cell‐derived hepatocytes as a renewable source of cells for therapy. In addition to cell‐based therapies, in vitro engineered liver tissue provides powerful models for human drug discovery and disease modeling. This review focuses on the generation of hepatocyte‐like cells from pluripotent stem cells and their application in translational medicine. Stem Cells 2016;34:1421–1426

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“…Proliferating HPCs are bipotent and give rise to both hepatocytes and cholangiocytes. 92 The actual origin of those cells and their markers are still debated. [92][93][94] Understanding the dynamics of HPC-mediated regeneration has been hampered by the lack of appropriate mouse models.…”

Section: Other Immune Cellsmentioning

confidence: 99%

Regression of Liver Fibrosis

2017

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Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional failure and the development of life-threatening complications. However, compelling evidence from rodent models and human studies indicates that if the injury is removed liver fibrosis is reversible. Hepatocytes, activated hepatic stellate cells, endothelial and immune cells, particularly macrophages, cooperate in the establishment and resolution of liver fibrosis. Here the authors provide a short overview of the mechanisms regulating the profibrotic and proresolution response, with the aim of highlighting potential new therapeutic targets. Liver disease is a major unmet medical need; currently, the sole approaches are the withdrawal of the injurious stimulus and liver transplantation. The authors conclude with a brief review of the feasibility of macrophage-based cell therapy for liver fibrosis.

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Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin

Cited by 29 publications

References 82 publications

Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice

Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice

Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine

Regression of Liver Fibrosis

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Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin

Cited by 29 publications

References 82 publications

Immunohistochemical biomarkers and distribution of telocytes in ApoE−/− mice

Immunohistochemical biomarkers and distribution of telocytes in ApoE−/− mice

Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine

Regression of Liver Fibrosis

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Product

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Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice

Immunohistochemical biomarkers and distribution of telocytes in ApoE^−/− mice