Advances in liposomes loaded with photoresponse materials for cancer therapy

Zhang, Xianwei; Ma, Youfu; Shi, Yenong; Jiang, Lihe; Wang, Lisheng; ur Rashid, Haroon; Yuan, Mingqing; Liu, Xu

doi:10.1016/j.biopha.2024.116586

Cited by 4 publications

(1 citation statement)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the hypoxic TME can limit PDT effectiveness. 143 Yuan et al 144 addressed this by preparing the nano composites of PSs mTHPC and BU (T-B@NP) for combined chemo-PDT therapy. The singlet oxygen quantum yield of T-B@NP was only slightly lower than free mTHPC (0.36 vs 0.43), and its good ROS generation ability provides an important basis for PDT research.…”

Section: Stimuli-responsive Targeted Drug Delivery Systemsmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

show abstract

Section: Stimuli-responsive Targeted Drug Delivery Systemsmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Progress and promise of photoresponsive nanocarriers for precision drug delivery in cancer

Thakur,

Saleh,

Khan

et al. 2024

Journal of Photochemistry and Photobiology C: Photochemistry Re

View full text Add to dashboard Cite

Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

Kejík,

Hajduch,

Abramenko

et al. 2024

Commun Chem

View full text Add to dashboard Cite

Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.

show abstract

Advances in liposomes loaded with photoresponse materials for cancer therapy

Cited by 4 publications

References 118 publications

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Progress and promise of photoresponsive nanocarriers for precision drug delivery in cancer

Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

Contact Info

Product

Resources

About