Advances in Label-Free Detections for Nanofluidic Analytical Devices

Le, Thu Hac Huong; Shimizu, Hisashi; Morikawa, Kyojiro

doi:10.3390/mi11100885

Cited by 20 publications

(7 citation statements)

References 131 publications

(153 reference statements)

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“…Nanofluidic systems are currently being explored for novel functionalities and applications owing to its unique properties that are not observed in microscale or bulk solutions. 47 By combining these features with the biomimetic characteristics of SLBs, these platforms have promising potentials for the analysis of biological molecules.…”

Section: Confinement Of Lipid Membranes In a Nanoscopic Spacementioning

confidence: 99%

Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform

Morigaki

2021

ANAL. SCI.

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Synthetic model systems of the biological membranes, such as Langmuir monolayer, lipid vesicle, and black lipid membrane (BLM), have played important roles in understanding the structures and functions of the biological membranes. 8 They also provide platforms for biosensing and biomedical applications by mimicking the membrane functions. Substratesupported lipid bilayers (SLBs), a relatively new breed of the model membranes introduced in 1980's, 9,10 typically comprise a single lipid bilayer adsorbed on a solid surface by physical

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Section: Confinement Of Lipid Membranes In a Nanoscopic Spacementioning

confidence: 99%

Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform

Morigaki

2021

ANAL. SCI.

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“…Since the 2000s, the field of nanofluidics has advanced with downscaling of microfluidics [ 16 , 17 , 18 , 19 , 20 ]. Compared to microspaces, size confinement effects are much more enhanced in nanospaces.…”

Section: Introductionmentioning

confidence: 99%

Metal-Free Fabrication of Fused Silica Extended Nanofluidic Channel to Remove Artifacts in Chemical Analysis

et al. 2021

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In microfluidics, especially in nanofluidics, nanochannels with functionalized surfaces have recently attracted attention for use as a new tool for the investigation of chemical reaction fields. Molecules handled in the reaction field can reach the single–molecule level due to the small size of the nanochannel. In such surroundings, contamination of the channel surface should be removed at the single–molecule level. In this study, it was assumed that metal materials could contaminate the nanochannels during the fabrication processes; therefore, we aimed to develop metal-free fabrication processes. Fused silica channels 1000 nm-deep were conventionally fabricated using a chromium mask. Instead of chromium, electron beam resists more than 1000 nm thick were used and the lithography conditions were optimized. From the results of optimization, channels with 1000 nm scale width and depth were fabricated on fused silica substrates without the use of a chromium mask. In nanofluidic experiments, an oxidation reaction was observed in a device fabricated by conventional fabrication processes using a chromium mask. It was found that Cr6+ remained on the channel surfaces and reacted with chemicals in the liquid phase in the extended nanochannels; this effect occurred at least to the micromolar level. In contrast, the device fabricated with metal-free processes was free of artifacts induced by the presence of chromium. The developed fabrication processes and results of this study will be a significant contribution to the fundamental technologies employed in the fields of microfluidics and nanofluidics.

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“…A nanochannel has a typical diameter of 10-1000 nm and a volume on the femtoliter to picoliter scale. Such ultrasmall channels have led to the development of various new functional devices [1][2][3][4][5]. The basic technologies used to develop these functional devices include fabrication, flow control, and detection.…”

Section: Introductionmentioning

confidence: 99%

Surface Patterning of Closed Nanochannel Using VUV Light and Surface Evaluation by Streaming Current

et al. 2021

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In nanofluidics, surface control is a critical technology because nanospaces are surface-governed spaces as a consequence of their extremely high surface-to-volume ratio. Various surface patterning methods have been developed, including patterning on an open substrate and patterning using a liquid modifier in microchannels. However, the surface patterning of a closed nanochannel is difficult. In addition, the surface evaluation of closed nanochannels is difficult because of a lack of appropriate experimental tools. In this study, we verified the surface patterning of a closed nanochannel by vacuum ultraviolet (VUV) light and evaluated the surface using streaming-current measurements. First, the C18 modification of closed nanochannels was confirmed by Laplace pressure measurements. In addition, no streaming-current signal was detected for the C18-modified surface, confirming the successful modification of the nanochannel surface with C18 groups. The C18 groups were subsequently decomposed by VUV light, and the nanochannel surface became hydrophilic because of the presence of silanol groups. In streaming-current measurements, the current signals increased in amplitude with increasing VUV light irradiation time, indicating the decomposition of the C18 groups on the closed nanochannel surfaces. Finally, hydrophilic/hydrophobic patterning by VUV light was performed in a nanochannel. Capillary filling experiments confirmed the presence of a hydrophilic/hydrophobic interface. Therefore, VUV patterning in a closed nanochannel was demonstrated, and the surface of a closed nanochannel was successfully evaluated using streaming-current measurements.

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Advances in Label-Free Detections for Nanofluidic Analytical Devices

Cited by 20 publications

References 131 publications

Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform

Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform

Metal-Free Fabrication of Fused Silica Extended Nanofluidic Channel to Remove Artifacts in Chemical Analysis

Surface Patterning of Closed Nanochannel Using VUV Light and Surface Evaluation by Streaming Current

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