Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

Johnson, Richard R.; Watt, R.; Kovač, Branka; Zyuzin, A. Yu.; Lier, Erik van; Erdman, K. L.; Gyles, W.; Sabaiduc, V.; McQuarrie, S.A.; Wilson, John S.; Backhouse, C.; Gelbart, W.; Kuo, T.

doi:10.1016/j.nimb.2007.04.022

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Examples of such studies include the Te(70)/Tl(30) eutectic (m.p. 224 ºC) investigated by Zyuzin et al and Johnson et al [ 54 , 55 ], the TeO 2 -based target system (m.p. 733 ºC) explored by Stevenson et al [ 53 ], and the tellurium metal-based system (m.p.…”

Section: Production Processing and Pet Imaging Of 124 mentioning

confidence: 99%

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

et al. 2010

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The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due to the unrivalled high sensitivity which allows for the studying of biochemistry in vivo on the molecular level. The most frequently used radionuclides for PET have relatively short half-lives (e.g. 11C: 20.4 min; 18F: 109.8 min) which may limit both the synthesis procedures and the time frame of PET studies. Iodine-124 (124I, t1/2 = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies. The present review gives a survey on the use of 124I as promising PET radionuclide for molecular imaging. The first part describes the production of 124I. The second part covers basic radiochemistry with 124I focused on the synthesis of 124I-labeled compounds for molecular imaging purposes. The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging.

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Section: Production Processing and Pet Imaging Of 124 mentioning

confidence: 99%

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

et al. 2010

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“…Such beams can be used in combination with superconducting triplet quadrupole ion separators 13 to isolate particular isotopes. As a result of new developments in cyclotron construction greater flexibility can now be achieved 14 in the production of a wide range of shortlived isotopes for radio-pharmaceutical use.…”

Section: Isotopesmentioning

confidence: 99%

“…Isotope production. The efficiency of various types of palladium based chromatographic columns for the separation of tritium 15 from other hydrogen isotopes has been reviewed whilst a new two-column method has been reported for the removal of contaminants that arise in fluorine-18 from the metallic cell window 14,16 under high beam current conditions. Improved procedures for the production of both 32 P 17 and 41 Ar 18 have been discussed and a novel method has been proposed 19 for making New York University (London), 6, Bedford Square, London, UK WC1B 3RA copper-64 using the [ 64 Zn(d,2p) 64 Cu] reaction followed by ion-exchange chromatography.…”

Section: Isotopesmentioning

confidence: 99%

Radiochemistry

Urch

2008

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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This year's report on recent progress in Radiochemistry considers radiochemical methods in isotope production, advances in labelling procedures, radioactive isotopes in the environment and miscellaneous topics of radiochemical interest. Radiation chemistry, neutron activation analysis and the chemistry of elements that happen to be radioactive will be eschewed. HighlightsThe labelling of glucose 91 with oxygen-15!-from cyclotron to product in just seven minutes. A solution to part of nuclear waste problem by transmutation of technetium 381 into a stable ruthenium isotope. And the possibility of varying 46 radioactive half-lives by chemical means-to be confirmed.

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