Abstract:Short CommunicationSince the first application of two photon intravital microscopy (2PM) to the study of the immune system in 1997 [1], 2PM imaging has offered several major advantages over previous techniques for study immune interactions. Such as 2D plate based culture systems, as cells exhibit significantly different migratory behavior in 2D as compared to 3D. Whilst, 3D matrigel systems allow cells to migrate in a more natural manner, they fail to adequately replicate a physiological environment which is d… Show more
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