Advances in implant surface modifications to improve osseointegration

Zhu, Guang; Wang, Guocheng; Li, Jiao Jiao

doi:10.1039/d1ma00675d

Cited by 56 publications

(43 citation statements)

References 163 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many brand devices have been developed (e.g., TiOblast ® , Osseotite ® , Steri-Oss Etched ® , TiUnite ® , ITI-TPS ® , Laser-Lok ® , SLActive ® ) [2], in order to improve the effectiveness of the dental implants and their rate of success. Besides, recent developments including a variety of surface modifications for dental implantology have been made to cope with the fact of being biologically inert, such as acid etching/grit blasting, hydrogen peroxide or acidic treatment, alternative nitride, hydroxyapatite or metal-based coatings among others [40][41][42][43][44][45].…”

Section: Historical Overview Of Implantologymentioning

confidence: 99%

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

View full text Add to dashboard Cite

An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.

show abstract

Section: Historical Overview Of Implantologymentioning

confidence: 99%

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Higher values of DNA extracted from “Pre-mineralized” surfaces indicate enhanced cell proliferation as compared to the other samples. We attribute this enhanced level of total DNA to the bioactive nature of CaP mineral ( Jeong et al, 2019 ) which has been reported to promote osseointegration ( Zhu et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration

Hasan

Bagnol

Owen

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Design and fabrication of implants that can perform better than autologous bone grafts remain an unmet challenge for the hard tissue regeneration in craniomaxillofacial applications. Here, we report an integrated approach combining additive manufacturing with supramolecular chemistry to develop acellular mineralizing 3D printed scaffolds for hard tissue regeneration. Our approach relies on an elastin-like recombinamer (ELR) coating designed to trigger and guide the growth of ordered apatite on the surface of 3D printed nylon scaffolds. Three test samples including a) uncoated nylon scaffolds (referred to as “Uncoated”), b) ELR coated scaffolds (referred to as “ELR only”), and c) ELR coated and in vitro mineralized scaffolds (referred to as “Pre-mineralized”) were prepared and tested for in vitro and in vivo performance. All test samples supported normal human immortalized mesenchymal stem cell adhesion, growth, and differentiation with enhanced cell proliferation observed in the “Pre-mineralized” samples. Using a rabbit calvarial in vivo model, ‘Pre-mineralized’ scaffolds also exhibited higher bone ingrowth into scaffold pores and cavities with higher tissue-implant integration. However, the coated scaffolds (“ELR only” and “Pre-mineralized”) did not exhibit significantly more new bone formation compared to “Uncoated” scaffolds. Overall, the mineralizing coating offers an opportunity to enhance integration of 3D printed bone implants. However, there is a need to further decipher and tune their immunologic response to develop truly osteoinductive/conductive surfaces.

show abstract

“…Implant surfaces have been modified in various ways to improve osseointegration and the biological process. In clinical practice, there is a strong need for an implant that increases osseointegration, with reduced waiting time from insertion to implant loading, especially in areas with low bone density and low primary stability or in patients with systemic diseases that can affect the bone healing process [ 11 , 93 , 94 ].…”

Section: Implant Surface Modificationsmentioning

confidence: 99%

Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

Cruz

Silva²,

Marques³

et al. 2022

Biomimetics

View full text Add to dashboard Cite

Background: The increased use of dental implants in oral rehabilitation has been followed by the development of new biomaterials as well as improvements in the performance of biomaterials already in use. This triggers the need for appropriate analytical approaches to assess the biological and, ultimately, clinical benefits of these approaches. Aims: To address the role of physical, chemical, mechanical, and biological characteristics in order to determine the critical parameters to improve biological responses and the long-term effectiveness of dental implant surfaces. Data sources and methods: Web of Science, MEDLINE and Lilacs databases were searched for the last 30 years in English, Spanish and Portuguese idioms. Results: Chemical composition, wettability, roughness, and topography of dental implant surfaces have all been linked to biological regulation in cell interactions, osseointegration, bone tissue and peri-implant mucosa preservation. Conclusion: Techniques involving subtractive and additive methods, especially those involving laser treatment or embedding of bioactive nanoparticles, have demonstrated promising results. However, the literature is heterogeneous regarding study design and methodology, which limits comparisons between studies and the definition of the critical determinants of optimal cell response.

show abstract

Advances in implant surface modifications to improve osseointegration

Abstract: Metallic biomaterials are widely used in implants to strengthen, repair, or replace damaged bone tissue, and their material characteristics have direct influences on short- and long-term implant performance. Of these,...

Cited by 56 publications

References 163 publications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration

Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

Contact Info

Product

Resources

About