Advances in imaging and treatment of atherosclerosis based on organic nanoparticles

Tu, Shuangshuang; He, Wenming; Han, Jinru; Wu, Aiguo; Ren, Wenzhi

doi:10.1063/5.0127835

Cited by 9 publications

(12 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to micelles, organic nanoparticles also include polymeric NPs, liposomes, and high-density lipoprotein NPs[ 116 ]. Liposomes have been intensively studied since their discovery.…”

Section: Ros Responsive Strategies For As Treatmentmentioning

confidence: 99%

Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis

Wu,

Mao,

Wang

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

The development of atherosclerosis (AS) is closely linked to changes in the plaque microenvironment, which consists primarily of the cells that form plaque and the associated factors they secrete. The onset of inflammation, lipid deposition, and various pathological changes in cellular metabolism that accompany the plaque microenvironment will promote the development of AS. Numerous studies have shown that oxidative stress is an important condition that promotes AS. The accumulation of reactive oxygen species (ROS) is oxidative stress’s most important pathological change. In turn, the effects of ROS on the plaque microenvironment are complex and varied, and these effects are ultimately reflected in the promotion or inhibition of AS. This article reviews the effects of ROS on the microenvironment of atherosclerotic plaques and their impact on disease progression over the past five years and focuses on the progress of treatment strategies based on scavenging ROS of nanoparticles for AS. Finally, we also discuss the prospects and challenges of AS treatment.

show abstract

Section: Ros Responsive Strategies For As Treatmentmentioning

confidence: 99%

Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis

Wu,

Mao,

Wang

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Detection of nanoprobes can be accomplished by a variety of methods. Moreover, the successful imaging of monocytes, macrophages, foam cells, and other plaque components, has enabled these nanoprobes to become promising in realizing the visualization of plaques, especially in the early stage of atherosclerosis 41 . Secondly, nanoprobes can act as efficient carriers for anti-inflammation and anti-lipid metabolism drug delivery, assisting in achieving therapeutic purposes 41 , 42 .…”

Section: General Overview Of Theranostic Applications Of Engineering ...mentioning

confidence: 99%

“…Moreover, the successful imaging of monocytes, macrophages, foam cells, and other plaque components, has enabled these nanoprobes to become promising in realizing the visualization of plaques, especially in the early stage of atherosclerosis 41 . Secondly, nanoprobes can act as efficient carriers for anti-inflammation and anti-lipid metabolism drug delivery, assisting in achieving therapeutic purposes 41 , 42 . In this sense, organic nanoparticles are classical examples to provide both platforms for improved detection (molecular imaging) and more efficacious treatment (drug delivery) of atherosclerosis, owing to their intrinsic physical properties, i.e.…”

Section: General Overview Of Theranostic Applications Of Engineering ...mentioning

confidence: 99%

“…In this sense, organic nanoparticles are classical examples to provide both platforms for improved detection (molecular imaging) and more efficacious treatment (drug delivery) of atherosclerosis, owing to their intrinsic physical properties, i.e. superior biocompatibility, and drug-loading capacity 41 , 43 , 44 . To sum up, these engineering nanoprobes can function as potential carriers for both imaging and therapeutic agents for atherosclerotic plaques, in turn extending their traditional clinical applications in this field.…”

Section: General Overview Of Theranostic Applications Of Engineering ...mentioning

confidence: 99%

See 1 more Smart Citation

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Zan¹,

An²,

Wu³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

Atherosclerosis, an inflammation-driven chronic blood vessel disease, is a major contributor to devastating cardiovascular events, bringing serious social and economic burdens. Currently, non-invasive diagnostic and therapeutic techniques in combination with novel nanosized materials as well as established molecular targets are under active investigation to develop integrated molecular imaging approaches, precisely visualizing and/or even effectively reversing early-stage plaques. Besides, mechanistic investigation in the past decades provides many potent candidates extensively involved in the initiation and progression of atherosclerosis. Recent hotly-studied imaging nanoprobes for detecting early plaques mainly including optical nanoprobes, photoacoustic nanoprobes, magnetic resonance nanoprobes, positron emission tomography nanoprobes, and other dual- and multi-modality imaging nanoprobes, have been proven to be surface functionalized with important molecular targets, which occupy tailored physical and biological properties for atherogenesis. Of note, these engineering nanoprobes provide long blood-pool residence and specific molecular targeting, which allows efficient recognition of early-stage atherosclerotic plaques and thereby function as a novel type of precise diagnostic tools as well as potential therapeutic carriers of anti-atherosclerosis drugs. There have been no available nanoprobes applied in the clinics so far, although many newly emerged nanoprobes, as exemplified by aggregation-induced emission nanoprobes and TiO 2 nanoprobes, have been tested for cell lines in vitro and atherogenic animal models in vivo , achieving good experimental effects. Therefore, there is an urgent call to translate these preclinical results for nanoprobes into clinical trials. For this reason, this review aims to give an overview of currently investigated nanoprobes in the context of atherosclerosis, summarize relevant published studies showing applications of different kinds of formulated nanoprobes in early detection and reverse of plaques, discuss recent advances and some limitations thereof, and provide some insights into the development of the new generation of more precise and efficient molecular nanoprobes, with a critical property of specifically targeting early atherosclerosis.

show abstract

“…Noninvasive early diagnosis can prevent the progression of CAD and effectively reduce its mortality rate, but currently there not a reliable and stable noninvasive clinical diagnostic marker in. 3 The most basic pathological mechanism of CAD is atherosclerosis, and the immune response plays an essential role in the formation and development of atherosclerosis. 4 At present, it is believed that the inflammatory process induced by atherosclerotic lesions is mediated by cells of the innate and adaptive immune system that are recruited into the arterial intima.…”

Section: Introductionmentioning

confidence: 99%

Immune Cell Infiltration Analysis Based on Bioinformatics Reveals Novel Biomarkers of Coronary Artery Disease

He,

Muhetaer,

et al. 2023

JIR

View full text Add to dashboard Cite

Background: Coronary artery disease (CAD) is a multifactorial immune disease, but research into the specific immune mechanism is still needed. The present study aimed to identify novel immune-related markers of CAD. Methods: Three CAD-related datasets (GSE12288, GSE98583, GSE113079) were downloaded from the Gene Expression Integrated Database. Gene ontology annotation, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and weighted gene coexpression network analysis were performed on the common significantly differentially expressed genes (DEGs) of these three data sets, and the most relevant module genes for CAD obtained. The immune cell infiltration of module genes was evaluated with the CIBERSORT algorithm, and characteristic genes accompanied by their diagnostic effectiveness were screened by the machine-learning algorithm least absolute shrinkage and selection operator (LASSO) regression analysis. The expression levels of characteristic genes were evaluated in the peripheral blood mononuclear cells of CAD patients and healthy controls for verification. Results: A total of 204 upregulated and 339 downregulated DEGs were identified, which were mainly enriched in the following pathways: "Apoptosis", "Th17 cell differentiation", "Th1 and Th2 cell differentiation", "Glycerolipid metabolism", and "Fat digestion and absorption". Five characteristic genes, LMAN1L, DOK4, CHFR, CEL and CCDC28A, were identified by LASSO analysis, and the results of the immune cell infiltration analysis indicated that the proportion of immune infiltrating cells (activated CD8 T cells and CD56 DIM natural killer cells) in the CAD group was lower than that in the control group. The expressions of CHFR, CEL and CCDC28A in the peripheral blood of the healthy controls and CAD patients were significantly different. Conclusion:We identified CHFR, CEL and CCDC28A as potential biomarkers related to immune infiltration in CAD based on public data sets and clinical samples. This finding will contribute to providing a potential target for early noninvasive diagnosis and immunotherapy of CAD.

show abstract

Advances in imaging and treatment of atherosclerosis based on organic nanoparticles

Cited by 9 publications

References 130 publications

Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis

Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Immune Cell Infiltration Analysis Based on Bioinformatics Reveals Novel Biomarkers of Coronary Artery Disease

Contact Info

Product

Resources

About