Advances in image-guided drug delivery for antibacterial therapy

Huang, Haiyan; Ali, Arbab; Liu, Yi; Xie, Hui; Ullah, Sana; Roy, Shubham; Song, Zhiyong; Guo, Bing; Xu, Jian

doi:10.1016/j.addr.2022.114634

Cited by 26 publications

(24 citation statements)

References 229 publications

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“…194 In addition to photodynamic properties, nanomaterials possess chemodynamic properties against bacteria and their biofilms. Huang et al (2023) conducted a comprehensive survey of state-of-the-art image-guided techniques for diagnosing and treating bacterial infections, including photothermal treatment, photodynamic therapy, chemodynamic therapy, sonodynamic therapy, immunotherapy, and various other therapies. 195 Along with these advanced therapies, researchers have also focused on utilizing the physiochemical properties of NPs to release drugs through various stimuli such as sound, light, pH, electric, and magnetic fields to overcome multidrug resistance.…”

Section: Acsmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Section: Acsmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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“…132,133 Furthermore, some groups are working on image-guided therapeutic approaches for this purpose. 134…”

Section: Challenges and Plausible Remediesmentioning

confidence: 99%

“…132,133 Furthermore, some groups are working on image-guided therapeutic approaches for this purpose. 134 Moreover, some PTT systems cannot target the infection sites properly, and thus the efficacy of the treatment gets lowered. 135 Herein, multimodal PTT strategies have become famous.…”

Section: Challenges and Plausible Remediesmentioning

confidence: 99%

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Roy

Guo

2023

J. Mater. Chem. B

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“…i Photothermal stability of Rp@Al under an 808-nm laser with a power density of 2 W/cm 2 for four irradiation/cooling cycles. j Photothermal conversion efficiency of Rp@Al organic and inorganic nanomaterials for antibacterial applications, as summarized in Table S2 [58,59], exhibiting prominent photothermal antibacterial and anti-biofilm abilities (Fig. 2e).…”

Section: Photothermal Antibacterial Activity Of Rp@al In Vitromentioning

confidence: 99%

Bacteria-based multiplex system eradicates recurrent infections with drug-resistant bacteria via photothermal killing and protective immunity elicitation

et al. 2023

Biomater Res

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Background The high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and the high incidence of recurrent infections. Methods Herein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed of natural Rhodopseudomonas palustris (Rp) and Food and Drug Administration-approved aluminum (Al) adjuvant, was developed to combat drug-resistant bacterial infections and prevent their recurrence. We examined its photothermal performance and in vitro and in vivo antibacterial ability; revealed its protective immunomodulatory effect; verified its preventative effect on recurrent infections; and demonstrated the system’s safety. Results Rp@Al exhibits excellent photothermal properties with an effective elimination of methicillin-resistant Staphylococcus aureus (MRSA). In addition, Rp@Al enhances dendritic cell activation and further triggers a T helper 1 (TH1)/TH2 immune response, resulting in pathogen-specific immunological memory against recurrent MRSA infection. Upon second infection, Rp@Al-treated mice show significantly lower bacterial burden, faster abscess recovery, and higher survival under near-lethal infection doses than control mice. Conclusions This innovative multiplex system, with superior photothermal and immunomodulatory effects, presents great potential for the treatment and prevention of drug-resistant bacterial infections. Graphical Abstract

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Advances in image-guided drug delivery for antibacterial therapy

Cited by 26 publications

References 229 publications

Advances in Nanotechnology for Biofilm Inhibition

Advances in Nanotechnology for Biofilm Inhibition

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Bacteria-based multiplex system eradicates recurrent infections with drug-resistant bacteria via photothermal killing and protective immunity elicitation

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