Advances in Hair Restoration

Krane, Natalie A.; Christofides, Elena A.; Halaas, Yael

doi:10.1007/s40136-021-00368-0

Cited by 2 publications

(4 citation statements)

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“…After their initial discovery in 1983 34 with a pivotal study demonstrating that exosomes are derived from mesenchymal stem cells and have the capacity to promote proliferation and survival of cells in 2009, 35 clinical trials investigating their therapeutic use have gained traction. There are currently no completed clinical trials regarding the use of exosomes for the treatment of hair loss; however, anecdotal evidence and case reports from various hair restoration specialists show promising results 36‐39 …”

Section: Resultsmentioning

confidence: 99%

“…There are currently no completed clinical trials regarding the use of exosomes for the treatment of hair loss; however, anecdotal evidence and case reports from various hair restoration specialists show promising results. [36][37][38][39] Additionally, several patents specific for the treatment of alopecia with exosomes are being developed. A European patented study demonstrated that a pharmaceutical composition comprising mesenchymal stem cell-derived exosomes may be capable of promoting hair growth in a mouse model.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…47,48 Various studies on exosomes have cited no significant adverse events, including a study assessing efficacy and safety of exosome technology as a carrier for melanoma vaccination; however, these studies were not conducted in alopecia patients. 8,49 Given that exosomes are used allogeneically and require manipulation, and have potential risks of transferring genetic information and activating immune responses, 37 the FDA has categorized them as drug products, requiring extensive review before approval. Furthermore, questions relating to their biodistribution and pharmacokinetic profile are still unanswered.…”

Section: Safetymentioning

confidence: 99%

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Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

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Background: Alopecia is a common chief complaint and is challenging to treat. As such, regenerative treatments to promote hair growth are an emerging area of research. Exosomes, which are extracellular vesicles involved in cell communication, homeostasis, differentiation, and organogenesis, have been shown to play a central role in hair morphogenesis and regeneration with potential for use as alopecia treatment.Aims: This review summarizes and assesses the body of literature surrounding exosomes as regenerative therapeutics for alopecia and identifies areas for improvement in future research.Methods: A review was conducted using a comprehensive list of keywords including "exosome," "alopecia," and "hair loss" on PubMed, EMBASE, and Google Scholar databases published from inception to February 2022. Reference lists of identified articles were included. 47 studies were included. Clinical trial databases were searched using the term "exosome"; however, no trials relevant to hair growth were identified.Results: Our updated and comprehensive review details the history of exosome use in medicine, postulated underlying mechanisms in treating hair loss, and current clinical studies. Preclinical studies demonstrate clear benefits of exosome therapeutics in regenerative medicine and for hair loss treatment. Clinical trials demonstrate safety of exosome use in medicine, but data showing efficacy and safety of exosome therapy for alopecia are lacking. We identified several gaps in knowledge required for effective clinical translation including safety, exosome source, and optimal treatment delivery mechanism and dosage. Conclusion:Exosomes are on the horizon as an exciting therapeutic for the treatment of alopecia. Further studies and clinical trials are required.

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Section: Resultsmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Section: Safetymentioning

confidence: 99%

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Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

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“…Although no clinical trials have been completed yet, anecdotal evidence and case reports suggest promising results 69 and initial studies indicate increased hair thickness and density after exosome therapy in individuals with pattern baldness. 70…”

Section: Aga Managementmentioning

confidence: 99%