Advances in gelatin-based hydrogels for wound management

Kang, Jeon Il; Park, Kyung Min

doi:10.1039/d0tb02582h

Cited by 115 publications

(67 citation statements)

References 85 publications

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“…ROS, the by-products of cellular metabolism, are potential antiviral targets [ 53 ], and several viral infections were shown to cause an increase in intracellular ROS, mainly due to viral-induced imbalances in the antioxidant defense mechanisms of the cell, thereby activating certain host cellular pathways and promoting viral replication [ 54 , 55 ]. Nano-sized iron (II) complex has been reported to possess excellent radical-scavenging activities and high antiviral activity against tobacco mosaic viruses (TMV) [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

et al. 2022

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Background The infection and spread of porcine reproductive and respiratory syndrome virus (PRRSV) pose a serious threat to the global pig industry, and inhibiting the viral infection process is a promising treatment strategy. Nanomaterials can interact with viruses and have attracted much attention due to their large specific surface area and unique physicochemical properties. Ferrous sulfide nanoparticles (FeS NPs) with the characteristics of high reactivity, large specific surface area, and low cost are widely applied to environmental remediation, catalysis, energy storage and medicine. However, there is no report on the application of FeS NPs in the antiviral field. In this study, gelatin stabilized FeS nanoparticles (Gel-FeS NPs) were large-scale synthesized rapidly by the one-pot method of co-precipitation of Fe2+ and S2‒. Results The prepared Gel-FeS NPs exhibited good stability and dispersibility with an average diameter of 47.3 nm. Additionally, they were characterized with good biocompatibility and high antiviral activity against PRRSV proliferation in the stages of adsorption, invasion, and replication. Conclusions We reported for the first time the virucidal and antiviral activity of Gel-FeS NPs. The synthesized Gel-FeS NPs exhibited good dispersibility and biocompatibility as well as effective inhibition on PRRSV proliferation. Moreover, the Fe2+ released from degraded Gel-FeS NPs still displayed an antiviral effect, demonstrating the advantage of Gel-FeS NPs as an antiviral nanomaterial compared to other nanomaterials. This work highlighted the antiviral effect of Gel-FeS NPs and provided a new strategy for ferrous-based nanoparticles against PRRSV. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

et al. 2022

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“…Gelatin has been investigated as a potentially promising polymer backbone for hydrogel synthesis due to its biocompatibility, biodegradability, and ease of chemical modification ( Kang and Park, 2021 ). This material is conventionally extracted from porcine, bovine, or fish collagen.…”

Section: Cell Delivery Methodsmentioning

confidence: 99%

Hydrogel Scaffolds to Deliver Cell Therapies for Wound Healing

Sivaraj

Chen

Chattopadhyay

et al. 2021

Front. Bioeng. Biotechnol.

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Cutaneous wounds are a growing global health burden as a result of an aging population coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches have been used to treat wounds due to their secretory, immunomodulatory, and regenerative effects, and recent studies have highlighted that delivery of stem cells may provide the most benefits. Delivering these cells to wounds with direct injection has been associated with low viability, transient retention, and overall poor efficacy. The use of bioactive scaffolds provides a promising method to improve cell therapy delivery. Specifically, hydrogels provide a physiologic microenvironment for transplanted cells, including mechanical support and protection from native immune cells, and cell–hydrogel interactions may be tailored based on specific tissue properties. In this review, we describe the current and future directions of various cell therapies and usage of hydrogels to deliver these cells for wound healing applications.

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“…Furthermore, it is readily soluble and displays amphoteric behavior at 37 • C [165]. For instance, due to their excellent fluid absorption capacity, gelatin-based hydrogels can be used as wound dressings [166]. The differing isoelectric point (pI) values of cationic and anionic gelatin (pI equal to pH 7-9 for type A and pH 4.7-5.1 for type B) should be considered when gelatin-based formulas are developed, since pI can affect the retention of gelatin's active components [167].…”

Section: Gelatin-based Hydrogelsmentioning

confidence: 99%

“…The relatively poor thermomechanical stability is one of gelatin hydrogel's drawbacks, but chemical functionalization and modification increase the durability of these hydrogels, and make them suitable for long-term biological applications [170]. Of note, gelatin's functional groups, including primary amine, carboxyl, and hydroxyl, enable its modification with various cross-linkers and therapeutic agents, making it an ideal candidate for tissue regeneration [166]. The hydrophobic amino acids of gelatin, such as tyrosine and proline, can be cross-linked using glutaraldehyde [171], diisocyanates [172], carbodiimides [173], and genipin [174].…”

Section: Gelatin-based Hydrogelsmentioning

confidence: 99%

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

et al. 2022

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The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents’ structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels’ structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted.

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Advances in gelatin-based hydrogels for wound management

Abstract: The normal wound healing process and the foreign body reaction to wound management materials.

Cited by 115 publications

References 85 publications

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

Hydrogel Scaffolds to Deliver Cell Therapies for Wound Healing

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

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