Advances in functional imaging of the human cerebellum

Diedrichsen, Jörn; Verstynen, Timothy D.; Schlerf, John E.; Wiestler, Tobias

doi:10.1097/wco.0b013e32833be837

Cited by 73 publications

(56 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Helmchen et al 27 used a 1.5T scanner, a fixed stimulus temperature for all subjects, and wholebrain spatial normalization. In this study, we used a 3T scanner, fixed pain-rating across subjects by varying temperature, used SUIT to spatially normalize the cerebellum, [19][20][21] and coupled a pain-eliciting stimulus and a warm stimulus with a force production task.…”

Section: Discussionmentioning

confidence: 99%

Pain and motor processing in the human cerebellum

Coombes

Misra²

2016

Pain

View full text Add to dashboard Cite

Pain-related adaptations in movement require a network architecture that allows for integration across pain and motor circuits. Previous studies addressing this issue have focused on cortical areas such as the midcingulate cortex. Here, we focus on pain and motor processing in the human cerebellum. The goal of this study was to identify areas of activation in the cerebellum, which are common to pain and motor processing, and to determine whether the activation is limited to the superior and inferior cerebellar motor maps or extends into multimodal areas of the posterior cerebellum. Our observations identified overlapping activity in left and right lobules VI and VIIb during pain and motor processing. Activation in these multimodal regions persisted when pain and motor processes were combined within the same trial, and activation in contralateral left lobule VIIb persisted when stimulation was controlled for. Functional connectivity analyses revealed significant correlations in the BOLD time series between multimodal cerebellar regions and sensorimotor regions in the cerebrum including anterior midcingulate cortex, supplementary motor area, and thalamus. The current findings are the first to show multimodal processing in lobules VI and VIIb for motor control and pain processing and suggest that the posterior cerebellum may be important in understanding pain-related adaptations in motor control.

show abstract

Section: Discussionmentioning

confidence: 99%

Pain and motor processing in the human cerebellum

Coombes

Misra²

2016

Pain

View full text Add to dashboard Cite

show abstract

“…These discrepancies in location could be due to inaccuracies in normalization. A systematic comparison between the most likely lobules after SPM normalization and the lobules in the atlas indicated that a coordinate-based assignment after SPM normalization would only be correct for 38% of the voxels (Diedrichsen et al 2010). The SUIT toolbox allows higher accuracy in determining the exact localization and might improve the determination of morphometric differences between smokers and never-smokers.…”

Section: Discussionmentioning

confidence: 99%

“…FreeSurfer) do not encompass the cerebellum. For VBM methods the small size of the functional regions in the cerebellum poses a particular challenge to inter-subject normalization (Diedrichsen et al 2010) but its results rely on accurate normalization of cerebellum which has been shown to be suboptimal in custom analysis (Diedrichsen 2006;Diedrichsen et al 2009). Recently, a spatially unbiased atlas template has been introduced that addresses these problems.…”

Section: Introductionmentioning

confidence: 99%

Brain grey matter deficits in smokers: focus on the cerebellum

et al. 2011

View full text Add to dashboard Cite

Structural cerebral deficiencies in smokers have been well characterized by morphometric investigations focussing on cortical and subcortical structures. Although the role of the cerebellum is increasingly noted in mental and addiction disorders, no reports exist regarding cerebellar alterations in smokers employing a methodology specifically designed to assess the cerebellar morphology. We acquired high-resolution MRI scans from 33 heavy smokers and 22 never-smokers and used a voxel-based morphometry (VBM) approach utilizing the Spatially Unbiased Infratentorial (SUIT) toolbox (Diedrichsen 2006) to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with smoking. Relative to never-smokers, smokers showed significant reductions of grey matter volume in the right cerebellum Crus I. The grey matter volume in Crus I correlated negatively with the amount of nicotine dependence as assessed by means of the Fagerström scale. Since Crus I has been identified as the cognitive division of the cerebellum, the structural deficit may in part mediate cognitive deficits previously reported in smokers. Of note, the dependence-related magnitude of the volume deficit may support the notion that the cerebellum is substantially involved in core mechanisms of drug dependence.

show abstract

“…This overall lack of convergence in quantitative meta-analyses stands in sharp contrast to a more consistent pattern in ROI-based analyses, which could be explained by methodological problems. For VBM methods, the small size of the subdivisions in the cerebellum poses a particular challenge to inter-subject normalization (Diedrichsen et al 2010). The results rely on accurate normalization of cerebellum which has been shown to be suboptimal in custom analyses (Diedrichsen 2006;Diedrichsen et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Reduction of cerebellar grey matter in Crus I and II in schizophrenia

et al. 2011

View full text Add to dashboard Cite

Structural deficiencies within the cerebellum have been associated with schizophrenia. Whereas several region-of-interest-based studies have shown deviations in cerebellar volume, meta-analyses on conventional whole-brain voxel-based morphometry (VBM) studies do not implicate abnormalities in the cerebellum. Since this discrepancy could be due to methodological problems of VBM, we used a cerebellum-optimized VBM procedure. We acquired high-resolution MRI scans from 29 schizophrenia patients and 45 healthy controls and used a VBM approach utilizing the Spatially Unbiased Infratentorial toolbox (Diedrichsen in Neuroimage 33:127-138, 2006). Relative to healthy controls, schizophrenia patients showed reductions of grey matter volume in the left cerebellum Crus I/II that were correlated with thought disorder (p < 0.05; one-sided) and performance in the Trail-making test B (p < 0.01). No cerebellar group differences were detected employing conventional whole-brain VBM. The results derived from the cerebellum analysis provide evidence for distinct grey matter deficits in schizophrenia located in Crus I/II. The association of this area with thought disorder and Trail-making performance supports the previously suggested role of the cerebellum in coordination of mental processes including disordered thought in schizophrenia. The failure of conventional VBM to detect such effects suggests that previous studies might have underestimated the importance of cerebellar structural deficits in schizophrenia.

show abstract

Advances in functional imaging of the human cerebellum

Abstract: Although these results clearly show the limitations of current approaches, they also show the potential of anatomical and functional MRI for the study of the human cerebellum.

Cited by 73 publications

References 45 publications

Pain and motor processing in the human cerebellum

Pain and motor processing in the human cerebellum

Brain grey matter deficits in smokers: focus on the cerebellum

Reduction of cerebellar grey matter in Crus I and II in schizophrenia

Contact Info

Product

Resources

About