Advances in Epidural Spinal Cord Stimulation to Restore Function after Spinal Cord Injury: History and Systematic Review

Mansour, Nadine; Pino, Isabela Peña; Freeman, David J.; Carrabre, Kailey; Venkatesh, Shivani; Darrow, David; Samadani, Uzma; Parr, Ann M.

doi:10.1089/neu.2022.0007

Cited by 9 publications

(9 citation statements)

References 71 publications

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“…Although the focus of this case report is to bring attention to the neuroplasticity that is available even in SCIs classified as an AIS-A, the implications of the reported observations are widespread. With the advancement of neuromodulation and positive outcomes obtained with epidural stimulation in individuals with motor complete injuries [40][41][42][43][44][45][46], greater attention and opportunities should be provided to individuals with AIS-A by rehabilitation services and insurance providers. The ability to pay for rehabilitation remains a large limitation for equal access to activity-based services across all injury severities, provided that those classified with a motor-complete SPI typically only have access to these services through self-pay or scholarship opportunities [47].…”

Section: Discussionmentioning

confidence: 99%

Sensory Information Modulates Voluntary Movement in an Individual with a Clinically Motor- and Sensory-Complete Spinal Cord Injury: A Case Report

Angeli,

Wagers,

Harkema

et al. 2023

JCM

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Motor recovery following a complete spinal cord injury is not likely. This is partially due to insurance limitations. Rehabilitation strategies for individuals with this type of severe injury focus on the compensation for the activities of daily living in the home and community and not on the restoration of function. With limited time in therapies, the initial goals must focus on getting the patient home safely without the expectation of recovery of voluntary movement below the level of injury. In this study, we report a case of an individual with a chronic, cervical (C3)-level clinically motor- and sensory-complete injury who was able to perform voluntary movements with both upper and lower extremities when positioned in a sensory-rich environment conducive to the specific motor task. We show how he is able to intentionally perform push-ups, trunk extensions and leg presses only when appropriate sensory information is available to the spinal circuitry. These data show that the human spinal circuitry, even in the absence of clinically detectable supraspinal input, can generate motor patterns effective for the execution of various upper and lower extremity tasks, only when appropriate sensory information is present. Neurorehabilitation in the right sensory–motor environment that can promote partial recovery of voluntary movements below the level of injury, even in individuals diagnosed with a clinically motor-complete spinal cord injury.

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Section: Discussionmentioning

confidence: 99%

Sensory Information Modulates Voluntary Movement in an Individual with a Clinically Motor- and Sensory-Complete Spinal Cord Injury: A Case Report

Angeli,

Wagers,

Harkema

et al. 2023

JCM

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“…The latter has been investigated for SCI since 2011. It was developed in the 1960s to treat chronic pain, but by chance and over time, the ability to evoke motor activity in individuals with SCI’s was detected ( Mansour et al, 2022 ). The hypothesis behind ESCS for the treatment of SCI is that afferents are electrically stimulated, which can thereby, via interneurons and latent residual supraspinal translesional connections, activate locomotor centers and thus initiate movement ( Hachmann et al, 2021 ).…”

Section: Neuromodulationmentioning

confidence: 99%

Advancements in neuroregenerative and neuroprotective therapies for traumatic spinal cord injury

Fischer,

Bättig,

Stienen

et al. 2024

Front. Neurosci.

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Traumatic spinal cord injuries (SCIs) continue to be a major healthcare concern, with a rising prevalence worldwide. In response to this growing medical challenge, considerable scientific attention has been devoted to developing neuroprotective and neuroregenerative strategies aimed at improving the prognosis and quality of life for individuals with SCIs. This comprehensive review aims to provide an up-to-date and thorough overview of the latest neuroregenerative and neuroprotective therapies currently under investigation. These strategies encompass a multifaceted approach that include neuropharmacological interventions, cell-based therapies, and other promising strategies such as biomaterial scaffolds and neuro-modulation therapies. In addition, the review discusses the importance of acute clinical management, including the role of hemodynamic management as well as timing and technical aspects of surgery as key factors mitigating the secondary injury following SCI. In conclusion, this review underscores the ongoing scientific efforts to enhance patient outcomes and quality of life, focusing on upcoming strategies for the management of traumatic SCI. Each section provides a working knowledge of the fundamental preclinical and patient trials relevant to clinicians while underscoring the pathophysiologic rationale for the therapies.

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“…cardiovascular, bowel, bladder, sexual) functions [3,4]. These interrelated dysfunctions have a profound impact on quality of life [5][6][7] increase overall disease burden and contribute to large healthcare-related expenditures [8,9].…”

Section: Introductionmentioning

confidence: 99%

REPORT-SCS: minimum reporting standards for spinal cord stimulation studies in spinal cord injury

Malik,

Samejima,

Shackleton

et al. 2024

J. Neural Eng.

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Objective:Electrical spinal cord stimulation (SCS) has emerged as a promising therapy for recovery of sensorimotor and autonomic dysfunctions following spinal cord injury (SCI). Despite the rise in studies using SCS for SCI complications, there are no standard guidelines for reporting SCS parameters in research publications, making it challenging to compare, interpret or reproduce reported effects across experimental studies.Approach:To develop guidelines for minimum reporting standards for SCS parameters in pre-clinical and clinical SCI research, we gathered an international panel of expert clinicians and scientists. Using a Delphi approach, we developed guideline items and surveyed the panel on their level of agreement for each item.Main Results:There was strong agreement on 26 of the 29 items identified for establishing minimum reporting standards for SCS studies. The guidelines encompass three major SCS categories: hardware, configuration and current parameters, and the intervention.Significance:Standardized reporting of stimulation parameters will ensure that SCS studies can be easily analysed, replicated, and interpreted by the scientific community, thereby expanding the SCS knowledge base and fostering transparency in reporting.

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Advances in Epidural Spinal Cord Stimulation to Restore Function after Spinal Cord Injury: History and Systematic Review

Cited by 9 publications

References 71 publications

Sensory Information Modulates Voluntary Movement in an Individual with a Clinically Motor- and Sensory-Complete Spinal Cord Injury: A Case Report

Sensory Information Modulates Voluntary Movement in an Individual with a Clinically Motor- and Sensory-Complete Spinal Cord Injury: A Case Report

Advancements in neuroregenerative and neuroprotective therapies for traumatic spinal cord injury

REPORT-SCS: minimum reporting standards for spinal cord stimulation studies in spinal cord injury

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