Advances in enzyme-free nucleic acid amplification-based fluorescent biosensors for real-time imaging of DNA repair enzymes in living cells

Zhang, Qian; Su, Cong; Qiu, Jian-Ge; Jiang, Bing-Hua; Zhang, Chun-yang

doi:10.1016/j.ccr.2023.215406

Cited by 9 publications

(2 citation statements)

References 124 publications

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“…Among the different biosensors under development for disease diagnosis, nucleic acid-based fluorescent biosensors have gained relevance, in particular for living sample analysis [ 150 ]. Within these biosensors, the hybridization chain reaction (HCR), an enzyme-free isothermal amplification method, is highlighted due to its potential in living imaging [ 151 ].…”

Section: Biomedical Applications Of Functionalized Vlpsmentioning

confidence: 99%

Tailored Viral-like Particles as Drivers of Medical Breakthroughs

Travassos,

Martins,

Fernandes

et al. 2024

IJMS

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Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to conventional nanoparticles due to their safety, biocompatibility, immunogenicity, structural stability, scalability, and versatility. Furthermore, VLPs can be surface-functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. This review aims to address the different types of surface functionalization of VLPs, highlighting the more recent cutting-edge technologies that have been explored for the design of tailored VLPs, their importance, and their consequent applicability in the medical field.

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Section: Biomedical Applications Of Functionalized Vlpsmentioning

confidence: 99%

Tailored Viral-like Particles as Drivers of Medical Breakthroughs

Travassos,

Martins,

Fernandes

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…6 Aptamers are a type of DNA or RNA oligonucleotides selected from libraries of oligonucleotides by the systematic evolution of ligands by exponential enrichment (SELEX), and they can bind to targets with high affinity and good selectivity. 7 The aptamer of OTA can transduce into an antiparallel G-quadruplex structure in the presence of OTA. 3,8 Recently, various aptasensors have been developed for the detection of OTA, including luminescent, 9 colorimetric, 10 and electrochemical methods.…”

mentioning

confidence: 99%