Advances in Electrostatic Spinning of Polymer Fibers Functionalized with Metal-Based Nanocrystals and Biomedical Applications

Li, Haojun; Xu, Meng; Zhang, Aiying; Zhang, Jiatao

doi:10.3390/molecules27175548

Cited by 11 publications

(6 citation statements)

References 108 publications

(128 reference statements)

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“…Current mainstream technology for the fabrication of nanofiber membrane is electrospinning and it is enabling continuous and nanoscale fibers to be produced from different types of polymers, which have already shown immense potential across the fields in environmental protection, biomedicine, microelectronics and so on [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

RSM to Explore the Influence Mechanism of Process Configuration and Fiber Diameter in a New Multi-needle Spinneret Electrospinning

Jiang,

Chen,

Wang

et al. 2024

Preprint

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Nowadays, Multi-needle electrospinning has used to be an efficient method for producing nanofiber membranes. But in the process, the fluctuation errors in electrospinning fluid flow rate have directly influence the membrane quality, which bringing instability and still have not been solved yet. For finding out the solution to the inaccurate flow control in multi-needle, it is necessary to develop a multi-stage flow runner spinneret for large-scale production of nanofiber membrane. At first, the paper uses the finite element software COMSOL to numerically simulate the polymer flow in the runner of spinneret. Based on it, the velocity field distribution curve was draw and the velocity instability coefficient of the polymer flow was attained, which are providing theoretical guidance for the optimal design of spinneret. Next, the response surface analysis method (RSM) was used to establish a regression model between the average diameter of the nanofiber membrane and the process parameters. Then, above regression model used to perform variance data processing between the average diameter and the process parameter configuration. After that, the 2D and 3D response surface profiles and the significance analysis were completed. Finally, the stability of the nanofibers production was improved, which attained the optimal adjustment of process configuration in multi-needle electrospinning.

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Section: Introductionmentioning

confidence: 99%

RSM to Explore the Influence Mechanism of Process Configuration and Fiber Diameter in a New Multi-needle Spinneret Electrospinning

Jiang,

Chen,

Wang

et al. 2024

Preprint

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“…In recent years, the use of membranes in various medical applications has been constantly evolving [ 8 , 9 , 10 , 11 , 12 , 13 ]. Membranes are defined as porous films that act as a separating barrier between two adjacent phases, capable of allowing the transport of substances from one phase to another in a selective manner [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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“…In recent years, the use of polymeric membranes in different medical applications has been constantly evolving [ 7 , 8 ]. One of these applications of polymeric membranes in the biomedical field is represented by the developing drug delivery system based on membranes or different separation interest molecules such as antibiotics or proteins [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Regeneration Membranes Loaded with Non-Antibiotic Anti-2 Microbials: A Review

Adamuz-Jiménez,

Manzano-Moreno,

Vallecillo

2023

Polymers

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Both guided bone and guided tissue regeneration are techniques that require the use of barrier membranes. Contamination and infection of the surgical area is one of the most feared complications. Some current lines of research focus on functionalizing these membranes with different antimicrobial agents. The objective of this study was to carry out a review of the use and antibacterial properties of regeneration membranes doped with antimicrobials such as zinc, silver, chlorhexidine, and lauric acid. The protocol was based on PRISMA recommendations, addressing the PICO question: “Do membranes doped with non-antibiotic antimicrobials have antibacterial activity that can reduce or improve infection compared to membranes not impregnated with said antimicrobial?” Methodological quality was evaluated using the RoBDEMAT tool. A total of 329 articles were found, of which 25 met the eligibility criteria and were included in this review. Most studies agree that zinc inhibits bacterial growth as it decreases colony-forming units, depending on the concentration used and the bacterial species studied. Silver compounds also decreased the secretion of proinflammatory cytokines and presented less bacterial adhesion to the membrane. Some concentrations of chlorhexidine that possess antimicrobial activity have shown high toxicity. Finally, lauric acid shows inhibition of bacterial growth measured by the disk diffusion test, the inhibition zone being larger with higher concentrations. Antimicrobial agents such as zinc, silver, chlorhexidine, and lauric acid have effective antibacterial activity and can be used to dope regenerative membranes in order to reduce the risk of bacterial colonization.

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Advances in Electrostatic Spinning of Polymer Fibers Functionalized with Metal-Based Nanocrystals and Biomedical Applications

Cited by 11 publications

References 108 publications

RSM to Explore the Influence Mechanism of Process Configuration and Fiber Diameter in a New Multi-needle Spinneret Electrospinning

RSM to Explore the Influence Mechanism of Process Configuration and Fiber Diameter in a New Multi-needle Spinneret Electrospinning

Polymeric Membranes for Biomedical Applications

Regeneration Membranes Loaded with Non-Antibiotic Anti-2 Microbials: A Review

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