Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration

Gainza, Garazi; Villullas, Silvia; Pedraz, José Luís; Hernández, Rosa María; Igartua, Manoli

doi:10.1016/j.nano.2015.03.002

Cited by 223 publications

(156 citation statements)

References 148 publications

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“…In-depth understanding of the proper soluble factor communication necessary, however, could lead to a more direct approach of delivering growth factors to the region, leveraging drug delivery paradigms that create spatiotemporal gradients. 119 These interventions are intended to mimic the signals that induce a stable cell mass that functions as a blastema.…”

Section: Translating Epimorphic Regenerationmentioning

confidence: 99%

Looking Ahead to Engineering Epimorphic Regeneration of a Human Digit or Limb

Quijano

Lynch

Allan

et al. 2016

Tissue Engineering Part B: Reviews

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Approximately 2 million people have had limb amputations in the United States due to disease or injury, with more than 185,000 new amputations every year. The ability to promote epimorphic regeneration, or the regrowth of a biologically based digit or limb, would radically change the prognosis for amputees. This ambitious goal includes the regrowth of a large number of tissues that need to be properly assembled and patterned to create a fully functional structure. We have yet to even identify, let alone address, all the obstacles along the extended progression that limit epimorphic regeneration in humans. This review aims to present introductory fundamentals in epimorphic regeneration to facilitate design and conduct of research from a tissue engineering and regenerative medicine perspective. We describe the clinical scenario of human digit healing, featuring published reports of regenerative potential. We then broadly delineate the processes of epimorphic regeneration in nonmammalian systems and describe a few mammalian regeneration models. We give particular focus to the murine digit tip, which allows for comparative studies of regeneration-competent and regeneration-incompetent outcomes in the same animal. Finally, we describe a few forward-thinking opportunities for promoting epimorphic regeneration in humans.

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Section: Translating Epimorphic Regenerationmentioning

confidence: 99%

Looking Ahead to Engineering Epimorphic Regeneration of a Human Digit or Limb

Quijano

Lynch

Allan

et al. 2016

Tissue Engineering Part B: Reviews

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“…Two parameters were varied: temperature (30°C, 36.5°C, 40°C) and pH (6,7,8). Thus, nine systems of artificially controlled release were obtained in which the variables, temperature and pH, were combined.…”

Section: Resultsmentioning

confidence: 99%

“…În gelurile astfel sintetizate, s-au înglobat lidocaină şi bupivacaină. Pentru analiza eliberării de anestezice sau realizat sisteme artificiale in vitro, la care s-a variat temperatura (30°C, 36.5°C, 40°C) şi pH-ul (6,7,8).…”

Section: Discussionunclassified

“…Currently, these materials are studied as potential systems for the controlled release of biologically active compounds, because of their basic characteristics, among which we mention the porosity of the matrix, bioavailability and biodegradability. They are synthetized under normal temperature and pressure conditions and silica gels are approved by the Food and Drug Administration (FDA) [7,8], being equally DOI: http://dx.doi.org/10.21454/rjaic.7518/232.vit tolerated by the human organism in oral, interstitial or topical administration. Porous silica gels are obtained by condensation and polycondensation of hydroxylated units obtained through the hydrolysis of some precursors [9,10].…”

Section: Introductionmentioning

confidence: 99%

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An in vitro study of the release capacity of the local anaesthetics from siloxane matrices

Preda

Rogobete

Săndesc

et al. 2016

Rom J Anaesth Int Care

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Aims. In the field of anaesthesia and intensive care, the controlled release systems capable of delivering constantly local anaesthetics are of interest because of the advantages brought to pain management. In this paper we presented the release profiles by usage of siloxane matrices of two common local anaesthetics, lidocaine and bupivacaine, analysed in vitro.Methods. The siloxane matrices were obtained in accordance with the methods described in the specialized literature, tetraethoxysilane (TEOS) and tetramethoxysilane (TMOS) were used as precursors. Lidocaine and bupivacaine were encapsulated in the synthesized gels. The controlled release was performed in vitro artificial systems in which temperature (30°C, 36.5°C, 40°C) and pH (6, 7, 8) have varied.Results. Following the analysis of the artificial systems similar profiles were highlighted for both local anaesthetics. Statistically significant differences were identified (p < 0.05) for systems where the release occurred at temperatures above 36.5°C. There were no statistically significant differences regarding the influence of pH, the type of the entrapped anaesthetic or the type of the precursor used in the synthesis of siloxane matrices.Conclusions. According to this experimental study, the pH, the type of precursor or the type of anaesthetic does not statistically influence the release profile from the studied system. In conclusion, these systems are promising for obtaining pharmaceutical preparations which can be used in current clinical practice. Several studies on controlled release siloxane systems should be carried out both in vitro and in vivo in order to exclude possible toxicity and histopathological effects.

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“…Currently, dextran is widely applied in fields of chemical, pharmaceutical, clinical and food industry playing the function of adjuvant, emulsifier, carrier, drug, stabilizer, and thickener of jam and ice cream [81,82]. Dextrans are colloidal, hydrophilic and water-soluble substances, and can be decomposed in human feces due to bacterial action [44]. Hence, various drug-dextran prodrugs could be able to keep integrity in stomach and the small intestine but release in colon [83].…”

Section: Dextran and Its Derivationmentioning

confidence: 99%