Advances in Drug Delivery Systems and Applications in Neurosurgery

Lazorthes, Y; Sallerin-Caute, B.; Verdié, J. C.; Bastide, Rémi

doi:10.1007/978-3-7091-6697-0_5

Cited by 18 publications

(3 citation statements)

References 73 publications

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“…Indeed, in the case of patients with initially good pain relief followed by secondary deterioration, apart from the progression of the disease, consideration must be given to a possible malfunction of the medication pump [15,26].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Becker

Jakob

Uhle

et al. 2000

Stereotact Funct Neurosurg

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The effectiveness of intrathecal opioid therapy when applied to different pain mechanisms, in particular neuropathic and nociceptive pain conditions, was studied retrospectively in 43 patients suffering from cancer pain. On the basis of clinical and radiological data, the pain mechanisms were categorized as nociceptive (n = 23) and neuropathic (n = 20). The average duration of treatment of nociceptive pain was 5 months, of neuropathic pain only 2.5 months. The initial median reduction of pain with intrathecal opioid therapy was 77.8% for nociceptive and 61.1% for neuropathic pain. Long-term results with patients suffering nociceptive pain showed a continuing good median pain reduction of 66.7%. Patients suffering from neuropathic pain showed poor long-term results (11.1% median pain reduction). Neuropathic pain in the extremities reacted least to the application of intrathecal opioids. Optimal results were obtained for nociceptive pain in the trunk area of the body.

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Section: Discussionmentioning

confidence: 99%

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Becker

Jakob

Uhle

et al. 2000

Stereotact Funct Neurosurg

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“…HSA-based nanoparticles can be well tolerated without any serious side effects, which is supported by clinical studies with registered HSA-based particle formulations such as Albunex. [18][19][20][21] Albumin has been shown to be biodegradable, nontoxic, easy to purify, and soluble in water, allowing ease of delivery by injection and thus an ideal candidate for nanoparticle preparation. Incorporation of suitable drugs in nanoparticles has been shown to protect the pharmacological active substances from degradation during storage as well as from early degradation/inactivation after injection.…”

Section: Sebak Et Almentioning

confidence: 99%

Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis

Sebak

Mirzaei²,

Malhotra³

et al. 2010

IJN

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Drug delivery systems such as nanoparticles can provide enhanced efficacy for anticancer agents. Noscapine, a widely used cough suppressant for decades has recently been shown to cause significant inhibition and regression of tumor volumes without any detectable toxicity in cells or tissues. Nanoparticles made of human serum albumin (HSA) represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug's bioavailability and distribution, and reducing the body's response towards drug resistance. In the present study, we report for the first time the incorporation and delivery of noscapine-loaded HSA nanoparticles to tumor cells. The nanoparticles were designed and optimized to achieve a particle size in the range of 150-300 nm with a drug-loading efficiency of 85%-96%. The nanoparticles were evaluated in vitro for their anticancer activity and efficacy on breast cancer cells.

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“…Surgical implantation of epi‐ or subdural cannular ports and pumps may partially solve this problem. However, the dosage of infused drug is usually not optimal, and, in addition, morbid complications commonly occur, including mechanical malfunctions and infections (15). With these concerns and the findings of our animal studies, the potential benefit of transplanting chromaffin cells as an endogenous source of pain‐reducing substances as a long‐term or permanent solution to stabilize, reduce, or eliminate exogenous opioid administration became apparent.…”

mentioning

confidence: 99%

Fine structure of host‐graft relationships between transplanted chromaffin cells and CNS

Pappas

1999

FASEB j.

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Our laboratory studies have shown that transplantation of adrenal medullary tissue or isolated chromaffin cells into central nervous system (CNS) pain modulatory regions (i.e., periaqueductal gray and subarachnoid lumbar spinal cord) can reduce pain sensitivity of rats in both acute and chronic pain. The analgesia produced by these transplants is thought to result from release of both opiate peptides and catecholamines. Morphologically, these animal studies also suggest that there is no development of tolerance over long periods of time, and the transplanted chromaffin cells appear to be robust and well integrated with the host tissue. In our initial clinical studies, where allografts of adrenal medullary tissue were transplanted intrathecally to relieve intractable cancer pain, patients obtained significant and long‐lasting pain relief. Increased cerebrospinal fluid (CSF) levels of metenkephalin were correlated with the decreased pain scores. Histology of autopsy tissue obtained from two patients with 1 year transplants revealed viable transplanted chromaffin cells. Because of the limited availability of human adrenal glands, sources of xenogeneic chromaffin cells will need to be identified if effective transplantation therapy for chronic pain is to be developed further.—Pappas, G. D. Fine structure of host‐graft relationships between transplanted chromaffin cells and CNS. FASEB J. 13 (Suppl.), S277‐S280 (1999)

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Advances in Drug Delivery Systems and Applications in Neurosurgery

Cited by 18 publications

References 73 publications

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis

Fine structure of host‐graft relationships between transplanted chromaffin cells and CNS

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