Advances in Diagnostics and Treatments in Horses and Foals with Gastric and Duodenal Ulcers

Camacho‐Luna, Pilar; Buchanan, Benjamin R.; Andrews, Frank M.

doi:10.1016/j.cveq.2017.11.007

Cited by 18 publications

(16 citation statements)

References 40 publications

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“…Gastric ulceration is commonly associated with a poor body condition 1,5,11,20,21,42 ; different studies have reported an increase in body weight after treatment, associated with an improvement in ulcer grades 13,16,23,41 . However, the results of the present study showed no significant difference in body weight before and after the treatment period, neither in the treatment group nor in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…The administration of the supplement was accompanied by changes in management, which could have contributed to the reduction of gastric mucosa lesions and hyperkeratosis; indeed, stall confinement, intermittent feeding, and high in carbohydrates diets are considered to be important risk factors for EGUS [40][41][42][43][44][45] ; therefore, increasing pasture turnout, providing ad libitum goodquality hay and reducing nonstructural carbohydrate intake may decrease the severity of EGUS. 1,21,40,41,46 However, the control group was also subjected to the same environmental and dietary modifications, without obtaining any improvement in ESGD grade: therefore, it is likely that the administration of Trophogast pellet had a decisive role in the healing of the squamous gastric mucosa. An improvement in the control group could also have been expected because of environmental and dietary changes.…”

Section: Discussionmentioning

confidence: 99%

“…13 Although mucosal ulcers may heal spontaneously, 15 this is uncommon in horses in training or racing, and medical treatment is therefore required: omeprazole, a proton pump inhibitor, is considered the drug of choice for prevention and treatment of squamous ulceration, acting by suppressing acid secretion. 1,5,11,[16][17][18][19][20][21][22] However, pharmacological treatment is expensive and may require prolonged administrations: therefore, interest in nutraceutical supplements with anti-ulcerogenic properties has increased and numerous studies have been carried out to evaluate their effectiveness in preventing and treating gastric ulceration. 13,15,[23][24][25][26][27][28][29] Trophogast pellet is a feed supplement designed to protect gastric mucosa, containing pectin, soy lecithin, zinc oxide and Castanea sativa Mill.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

et al. 2021

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Introduction: Equine squamous gastric disease (ESGD) may require prolonged treatments with acid suppressants; therefore, interest in nutraceutical supplements with anti-ulcerogenic properties has increased. This study aims to investigate the efficacy of Trophogast pellet for the treatment of ESGD in endurance horses. Material and methods: Fifteen endurance horses were included based on their gastroscopic examination and randomly assigned to a treatment group, receiving Trophogast pellet for 30 days together with management changes, or to a control group, only subjected to management modifications. At the end of treatment, gastroscopy was repeated. Scores were assigned according to the Equine Gastric Ulcer Council scoring system. All horses were weighed at the beginning and at the end of the study. ESGD grades and weight before and after treatment were compared. Results: At enrolment, median ESGD score in the treatment group was 2, while in the control group it was 1. After the treatment period, a significant decrease in ESGD grade was observed in the treatment group (median 1, p = 0.0078), while there was no change in the control group (median 2). No significant weight change was observed in either group. Conclusion: Trophogast pellet was effective at promoting healing of mild ESGD in endurance horses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

et al. 2021

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“…Gastroscopy was performed at either the owners' or veterinary surgeons' request for investigation of a variety of clinical signs that have been associated with EGUS, including acute or recurrent colic, poor appetite, weight loss, hair coat changes, poor performance, behavioural changes and pain on tightening of the girth (Murray et al 1989;Murray 2009;Hepburn 2012;Sykes and Jokisalo 2014;Camacho-Luna et al 2018).…”

Section: Methodsmentioning

confidence: 99%

A clinical audit of the prevalence of colic in the 48 hours after gastroscopy in 436 horses

Spanton¹,

Smith²,

Mair

2019

Equine Veterinary Education

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Gastroscopy is a routine technique performed in equine practice to evaluate the stomach and is the gold standard diagnostic test for equine gastric ulcer syndrome (EGUS). There are few publications on the safety of the technique and any associated complications, in particular colic. The objective of the study was to review all gastroscopic examinations performed at two equine clinics over a 5-year period, and to describe any colic episodes in the 48 h post gastroscopy. In this clinical audit, hospital databases were searched for animals that had a gastroscopic examination in the 5-year study period. Signalment, sedative drugs, stomach insufflation/deflation, gastroscopic findings, occurrence of colic in the 48 h post examination and any medication administered during that time were recorded. A total of 436 horses underwent 573 gastroscopic examinations during the study period. Post-gastroscopy colic was recorded in 17/573 examinations (2.9%); 16 were mild, but one (0.2%) required exploratory laparotomy. Cases of gastric impaction were more commonly associated with colic post gastroscopy. When examinations of horses with gastric impaction were excluded, the prevalence of colic post gastroscopy was 5/ 561 (0.9%). A limitation of the study was that variability in technique was likely, due to multiple different clinicians performing gastroscopic examinations. A study with a larger sample size is required to confirm the findings of this audit. Gastroscopy is a relatively safe procedure but there is a small risk of colic afterwards.

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“…Equine gastric ulcer syndrome (EGUS) is a broad term, commonly used to characterise erosive and ulcerative stomach diseases in horses. The nonglandular stomach (squamous mucosa), glandular stomach, terminal oesophagus, and proximal duodenum are relatively the most prevalent anatomical sites in which gastric disease may occur (Andrews et al 1999;Andrews et al 2005;Sykes et al 2015;Camacho-Luna et al 2018).…”

mentioning

confidence: 99%

Frequency of endoscopic findings of equine squamous gastric disease (ESGD) in rural horses and its association with Helicobacter pylori virulence genes

Rezazadeh¹,

Pourebrahimi²,

Ghotaslou³

et al. 2022

Vet. Med. - Czech

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Equine gastric ulcer syndrome (EGUS) is a multifactorial disorder and one of the most common diseases in horses. The objective of this research was to detect one of the potential risk factors of equine squamous gastric disease (ESGD), the Helicobacter pylori specific gene, and tracing the presence of the duodenal ulcer-promoting gene (dupA) as a possible virulence marker. Gastric fluid together with faecal samples were collected from twenty rural horses from around Tabriz, Iran. Throughout the endoscopic examinations, the type, numbers, severity, and the location of the lesions were documented. Nine of twenty horses exhibited macroscopic lesions in the squamous mucosa that were later classified into grades 1, 2, 3, and 4. Only three of these horses exhibited H. pylori in their gastric fluid samples, whereas all faecal samples were H. pylori-negative. All the H. pylori-positive cases manifested severe forms of ESGD (grades 3–4). The age and sex were both unrelated to the lesion severity and ESGD status in this study. Research is required to further discuss the virulence aspects of dupA regarding ESGD.

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Advances in Diagnostics and Treatments in Horses and Foals with Gastric and Duodenal Ulcers

Cited by 18 publications

References 40 publications

Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

A clinical audit of the prevalence of colic in the 48 hours after gastroscopy in 436 horses

Frequency of endoscopic findings of equine squamous gastric disease (ESGD) in rural horses and its association with Helicobacter pylori virulence genes

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