Advances in Development of Dopaminergic Aporphinoids

Zhang, Ao; Zhang, Yi; Branfman, Alan R.; Baldessarini, Ross J.; Neumeyer, John L.

doi:10.1021/jm060959i

Cited by 102 publications

(43 citation statements)

References 94 publications

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“…It could be inferred that cytotoxicity of aporphine alkaloids with 1-OH was stronger than those with 1-OCH 3 . And the potential drug targets of these compounds in cell might related with D2 receptor [25]. …”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Sun

Jiang

Zhang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC50 values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μM, respectively.

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Section: Resultsmentioning

confidence: 99%

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Sun

Jiang

Zhang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Both agonistic and antagonistic activities have been described, depending on the particular aporphinoid. An excellent compilation of activities of natural and synthetic aporphinoids against dopamine receptors has been provided by Zhang et al [78]. Laurolitsine ( 32 ), for example, displayed IC 50 values of 2.6 and 6.8 µM against dopamine D1 and D2 receptors, respectively.…”

Section: 5 Isoquinoline Alkaloidsmentioning

confidence: 99%

Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities

Nikolić

Lankin

Cisowska

et al. 2015

The Formation, Structure and Activity of Phytochemicals

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The roots/rhizomes of black cohosh (Actaea racemosa L. syn. Cimicifuga racemosa [L]. Nutt., Ranunculaceae) have been used traditionally by Native Americans to treat colds, rheumatism, and a variety of conditions related to women’s health. In recent years black cohosh preparations have become popular dietary supplements among women seeking alternative treatments for menopausal complaints. The popularity of the plant has led to extensive phytochemical and biological investigations, including several clinical trials. Most of the phytochemical and biological research has focused on two abundant classes of compounds: the triterpene glycosides and phenolic acids. A third group of phytoconstituents that has received far less attention consists of the alkaloids and related compounds that contain nitrogen. This chapter summarizes the current state of knowledge of the chemistry and biological activities associated with this group of constituents and provides some perspective on their significance for future research on this interesting plant.

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“…Vicodin) 3 aporphines ( e.g. apomorphine), 4 phenanthroindolizidine ( e.g. antofine) and phenanthroquinolizidine ( e.g.…”

Section: Introductionmentioning

confidence: 99%

The [5+5] route to the phenanthrene skeleton

Herndon

Dhakal

2016

Arkivoc

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This account describes the historical development of the coupling of γ,δ-unsaturated Fischer carbene complexes and o-alkynylbenzaldehydes, which directly affords hydrophenanthrene ring systems in a process where each reactant contributes five carbons to the newly-formed bicyclo[4.4.0]decane ring system. The process has been termed net [5+5] cycloaddition. Use of the reaction to produce various medicinally important natural products and/or their parent ring systems is discussed.

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Advances in Development of Dopaminergic Aporphinoids

Cited by 102 publications

References 94 publications

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities

The [5+5] route to the phenanthrene skeleton

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