Advances in development of a contraceptive vaccine against human chorionic gonadotropin

Abstract

Introduction: There is continuing need for contraceptives. According to World Health Organization, 210 million pregnancies occur each year, out of which some 80 million are unintended. A vaccine offering privacy and periodic intake would be an attractive proposition. Areas covered: The article is a brief review of three vaccines developed against human chorionic gonadotropin (hCG) with progressively better attributes. Clinical trials have proven in more than one country the complete safety and reversibility of the anti-hCG vaccine(s) in women. Vaccination does not entail any disturbance in levels of reproductive tract hormones of the woman or any disturbance in menstrual regularity and bleeding profiles. Phase II clinical trials show the effective prevention of pregnancy in sexually active women of proven fertility. A recombinant vaccine amenable to industrial production has been developed; it induces substantially higher antibody titers in mice of four different genetic strains than those required to prevent pregnancy in women. Rigorous toxicology studies have been completed on this vaccine in rodents and marmosets. Expert opinion: This unique vaccine, requiring periodic intake and demonstrating no impairment of ovulation, hormonal profiles and menstrual regularity, is on the verge of final clinical trials under the aegis of the Indian Council of Medical Research and should be a valuable addition to the available contraceptives.

Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology

“…However, chorionic gonadotropin (CG) is only secreted by the placenta of horses and primates. Exogenous gonadotropins are widely used in the treatment of infertility in humans and animals (Lunenfeld et al, 2019), and endogenous gonadotropins are targets for contraception (Talwar et al, 2015). Gonadotropins are important in the control of the efficacy of reproduction (fertility) in domestic animals (Sousa et al, 2016).…”

HCG Found in WHO Tetanus Vaccine in Kenya Raises Concern in the Developing World

“…In this paper, our main focus is on just one of the WHO contraceptive vaccines [10] [16] [26] and more specifically on speculation about whether or not it was deployed by the WHO in the five administrations of tetanus vaccine in the Kenya campaign of 2013-2015. Here we examine the relevant research and the best laboratory data available to us in order to form our best guess, the informed opinion in which the authors concur, concerning what the WHO may have actually done in the 1 Initially, several of us (Oller, Shaw, Tomljenovic, Clement, and Pillette) were jointly studying viral and bacteriological carriers being used to deliver toxicants (e.g., in anti-cancer chemotherapy) and/or genetically engineered medical products to the cells and tissues of human patients.…”

“…However, even if such a happy outcome were achieved, would it justify the WHO deception suspected by the Catholic Church? Open Access Library Journal ti-fertility" vaccine to a pregnant woman on the theory that it would cause an abortion as it does in experimental animal models [26].…”