Advances in developing metabolically engineered microbial platforms to produce fourth-generation biofuels and high-value biochemicals

Mehmood, Muhammad Aamer; Shahid, Ayesha; Malik, Sana; Wang, Ning; Javed, Muhammad Rizwan; Haider, Muhammad Nabeel; Verma, Pradeep; Ashraf, Muhammad; Habib, Nida; Syafiuddin, Achmad; Boopathy, Raj

doi:10.1016/j.biortech.2021.125510

Cited by 40 publications

(19 citation statements)

References 116 publications

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“…Specific microorganisms responsible on the degradation of the water quality parameters need to be identified in order to fully unlock the potential of eco‐enzyme in mediating iron contaminated environment. This is also useful to encourage the use of potential microorganisms for future applications (Aamer Mehmood et al., 2021; Shahid et al., 2021a; Shahid et al., 2021b; Syafiuddin et al., 2021). In general, this study provided a cheap alternative method for the remediation of polluted water compared to the existing methods available in literature (Al Farraj, Hadibarata, et al., 2019; Al Farraj, Elshikh, et al., 2019; Hadibarata et al., 2019; Mostafa et al., 2019; Ratnasari et al., 2021a; Ratnasari et al., 2021b; Syafiuddin & Boopathy, 2021; Syafiuddin & Fulazzaky, 2021; Syafiuddin et al., 2020; Syafiuddin et al., 2017; Syafiuddin et al., 2018).…”

Section: Resultsmentioning

confidence: 99%

Improving the water quality of iron‐containing ponds using fermented kitchen wastes

Yong

Halim

Liong³

et al. 2021

Environmental Quality Mgmt

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To elucidate the efficacy of eco-enzyme in mediating contaminated waters, an onsite investigation was conducted spanning over a 5-month duration on three ponds receiving iron-containing groundwater continuously. Eco-enzyme was applied at designated dosages and time. Water samples were collected fortnightly for in situ monitoring of water quality. Parameters determined included total suspended solids (TSS), pH, alkalinity, chemical oxygen demand (COD), biochemical oxygen demand (BOD 5 ), ammoniacal-nitrogen (NH 3 ), and dissolved oxygen. During the investigation, ecoenzyme application was halted for nearly a month owing to the enforcement of Movement Control Order to curb the rising Covid-19 cases. The results revealed that the application of eco-enzyme has improved the overall water quality of the three ponds.A 99.9% of TSS removal was achieved. For the other parameters measured, the concentration fluctuated over time and the water quality status of the pond interchanged between slightly polluted and clean. The elevation of the water quality was largely dependent on the frequency of the eco-enzyme application. This study, therefore, concludes that eco-enzyme possessed the capability to enhance the quality of contaminated water.

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Section: Resultsmentioning

confidence: 99%

Improving the water quality of iron‐containing ponds using fermented kitchen wastes

Yong

Halim

Liong³

et al. 2021

Environmental Quality Mgmt

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“…In agriculture, microalgal/cyanobacterial bioactive metabolites can be used as biofertilizers, biostimulants, or biopesticides [158]. In the biorefineries, these metabolites have immense potential to be used as an alternative fuel source [159][160][161][162], biohydrogen, biogas, bioethanol, biodiesel, and so on. In the cosmetics industry [163,164], the bioactive metabolites are being used in various body care products (skin protectants like sun screen lotions, bioshampoos, etc.)…”

Section: Other Potential Applications Of Cyanobacteria and Microalgaementioning

confidence: 99%

Identification and characterization of the novel bioactive compounds from microalgae and cyanobacteria for pharmaceutical and nutraceutical applications

et al. 2022

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Microalgae and cyanobacteria (blue‐green algae) are used as food by humans. They have gained a lot of attention in recent years because of their potential applications in biotechnology. Microalgae and cyanobacteria are good sources of many valuable compounds, including important biologically active compounds with antiviral, antibacterial, antifungal, and anticancer activities. Under optimal growth condition and stress factors, algal biomass produce varieties of potential bioactive compounds. In the current review, bioactive compounds production and their remarkable applications such as pharmaceutical and nutraceutical applications along with processes involved in identification and characterization of the novel bioactive compounds are discussed. Comprehensive knowledge about the exploration, extraction, screening, and trading of bioactive products from microalgae and cyanobacteria and their pharmaceutical and other applications will open up new avenues for drug discovery and bioprospecting.

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“…Nevertheless, commercial production is not yet viable, as the biofuel production costs remain high, and the complete process is still energy-intensive. A design of the entire biorefinery with detailed techno-economic analysis (TEA) is a key aspect that requires attention to perform the successful transition from the laboratory to the industrial scale …”

Section: Introductionmentioning

confidence: 99%

“…A design of the entire biorefinery with detailed techno-economic analysis (TEA) is a key aspect that requires attention to perform the successful transition from the laboratory to the industrial scale. 13 When considering biorefinery design based on microorganisms, it is critical to develop project objectives and strain metrics that incorporate technical and economic factors. 14 However, in the current global context of climate change and social inequality, it is imperative to also consider environmental and social dimensions.…”

Section: ■ Introductionmentioning

confidence: 99%

Process Systems Engineering Approach for the Sustainable Design of Cyanobacteria-Based Integrated Biorefineries and Their Heat Exchanger Network

Ramos,

Lasry Testa,

Ramos

et al. 2024

ACS Sustainable Chem. Eng.

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As climate change increasingly impacts the environment and society worldwide, advanced biofuels produced from cyanobacteria constitute a nature-based solution to the capture and storage of the atmospheric greenhouse gas carbon dioxide by continual or enhanced biological processes. We propose a mixedinteger nonlinear programming problem to address the optimal design of a biorefinery and its heat exchanger network based on Synechocystis sp. PCC 6803, aiming to maximize the sustainability net present value in a superstructure approach. The optimal scheme includes production of pigments and fourth-generation bioethanol, self-supply of energy, and recycling of enriched nutrient streams. Numerical results provide a sustainability net present value of 117.55 M USD, rendering a competitive fourth-generation bioethanol production cost of 0.40 USD/kg of bioethanol. Simultaneous heat integration improves the objective function, showing that reducing environmental burden has a greater impact than minimizing the capital investment in heat exchangers, compared to the case of no heat integration. Sensitivity analysis shows that further enhancement of Synechocystis' ethanol productivity is crucial to improve sustainability.

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Advances in developing metabolically engineered microbial platforms to produce fourth-generation biofuels and high-value biochemicals

Cited by 40 publications

References 116 publications

Improving the water quality of iron‐containing ponds using fermented kitchen wastes

Improving the water quality of iron‐containing ponds using fermented kitchen wastes

Identification and characterization of the novel bioactive compounds from microalgae and cyanobacteria for pharmaceutical and nutraceutical applications

Process Systems Engineering Approach for the Sustainable Design of Cyanobacteria-Based Integrated Biorefineries and Their Heat Exchanger Network

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