Advances in degradation behavior of biomedical magnesium alloys: A review

Dong, Jin‐Yong; Lin, Tao; Shao, Huiping; Wang, Hao; Wang, Xueting; Song, Ke; Li, Qianghua

doi:10.1016/j.jallcom.2022.164600

Cited by 68 publications

(34 citation statements)

References 106 publications

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“…Zn is a trace element in the human body necessary to maintain physiological function, with the characteristics of osteogenesis and antibacterial ability [ 7 , 8 ], and is mainly stored in bones and muscles (>85%). The Zn 2+ produced during the degradation of Mg-Zn alloy is excreted by the body’s metabolism and does not accumulate in the organs [ 9 ]. Both Mg and Zn have a hexagonal, close-packed (HCP) crystal structure.…”

Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

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Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Chen

Kolawole

et al. 2022

Materials

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In recent years, biodegradable magnesium (Mg) alloys have attracted the attention of many researchers due to their mechanical properties, excellent biocompatibility and unique biodegradability. Many Mg alloy implants have been successfully applied in clinical medicine, and they are considered to be promising biological materials. In this article, we review the latest research progress in biodegradable Mg alloys, including research on high-performance Mg alloys, bioactive coatings and actual or potential clinical applications of Mg alloys. Finally, we review the research and development direction of biodegradable Mg alloys. This article has a guiding significance for future development and application of high-performance biodegradable Mg alloys, promoting the future advancement of the magnesium alloy research field, especially in biomedicine.

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Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

“…Due to the presence of rare earth metal elements, Mg-RE-based alloys have high mechanical properties and corrosion resistance [ 9 , 29 ]. Researchers have developed some high-performance Mg-RE-based alloys, such as Mg-Nd-Zn-Zr, Mg-Gd-Dy-Zr, WE43, etc.…”

Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Chen

Kolawole

et al. 2022

Materials

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Section: Introductionmentioning

confidence: 99%

“…Magnesium (Mg) with biodegradability has gradually attracted extensive attention in biomedical filed ( Zhang et al, 2021a ; Dong et al, 2022a ). It not only exhibits mechanical performances similar to human bone (density of 1.74 g/cm 3 and elastic modulus of 41–45 GPa), but also shows good biocompatibility ( Chen et al, 2018 ; Dong et al, 2022a ). Mg is an essential nutrient for the human body to keep healthy, which can promote bone growth, enhances cell adhesion to biomaterials, and assists the differentiation and biomineralization of osteoblasts ( Schwalfenberg and Genuis, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

A review on magnesium alloys for biomedical applications

Zhang

Wang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Magnesium (Mg) and Mg alloys are considered as potential candidates for biomedical applications because of their high specific strength, low density, and elastic modulus, degradability, good biocompatibility and biomechanical compatibility. However, the rapid corrosion rate of Mg alloys results in premature loss of mechanical integrity, limiting their clinical application in load-bearing parts. Besides, the low strength of Mg alloys restricts their further application. Thus, it is essential to understand the characteristics and influencing factors of mechanical and corrosion behavior, as well as the methods to improve the mechanical performances and corrosion resistance of Mg alloys. This paper reviews the recent progress in elucidating the corrosion mechanism, optimizing the composition, and microstructure, enhancing the mechanical performances, and controlling the degradation rate of Mg alloys. In particular, the research progress of surface modification technology of Mg alloys is emphasized. Finally, the development direction of biomedical Mg alloys in the future is prospected.

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“…In recent years, Mg and its alloys have attracted much attention as biomedical implant materials due to their mechanical compatibility, biocompatibility and biodegradability [ 1 , 2 , 3 , 4 ]. Grain size is an important trait influencing the biodegradation rate in physiological environments for biodegradable biomedical metals [ 5 , 6 , 7 ]. The finer grain size has more grain boundary.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Biodegradation Rate and Grain Size Itself Excluding Other Structural Factors Caused by Alloying Additions and Deformation Processing for Pure Mg

Liu

Deng

et al. 2022

Materials

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This work studied the relationship between biodegradation rate and grain size itself, excluding other structural factors such as segregations, impure inclusions, second phase particles, sub-structures, internal stresses and textures caused by alloying additions and deformation processing for pure Mg. A spectrum of grain size was obtained by annealing through changing the annealing temperature. Grain boundary influenced the hardness and the biodegradation behavior. The hardness was grain size-dependent, following a typical Hall–Petch relation: HV=18.45+92.31d−12. The biodegradation rate decreased with decreasing grain size, following a similar Hall–Petch relation: Pi=0.17−0.68d−12 or Pw=1.34−6.17d−12. This work should be helpful for better controlling biodegradation performance of biodegradable Mg alloys through varying their grain size.

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Advances in degradation behavior of biomedical magnesium alloys: A review

Cited by 68 publications

References 106 publications

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

A review on magnesium alloys for biomedical applications

Relationship between Biodegradation Rate and Grain Size Itself Excluding Other Structural Factors Caused by Alloying Additions and Deformation Processing for Pure Mg

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