Advances in circular RNAs and their roles in breast Cancer

Wang, Xuehui; Fang, Lin

doi:10.1186/s13046-018-0870-8

Cited by 97 publications

(77 citation statements)

References 100 publications

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“…Only a small quantity of patients with metastatic breast cancer has been timely diagnosed. 5 Strikingly, it is currently acknowledged that circular RNAs (circRNAs) have implications in the pathogenesis of cancer progression, which highlighted their potential as novel biomarkers or therapeutic targets for breast cancer, 6 this brings an attractive focus to seek circRNAs-targeted strategies. 4 Even though the treatment options progressed in the recent decades, heterogeneity of metastatic breast cancer and specific molecular mutations in clinical situations have been identified, and personalized strategies are effective for only a few patients up to now.…”

Section: Introductionmentioning

confidence: 99%

“…4 Even though the treatment options progressed in the recent decades, heterogeneity of metastatic breast cancer and specific molecular mutations in clinical situations have been identified, and personalized strategies are effective for only a few patients up to now. 5 Strikingly, it is currently acknowledged that circular RNAs (circRNAs) have implications in the pathogenesis of cancer progression, which highlighted their potential as novel biomarkers or therapeutic targets for breast cancer, 6 this brings an attractive focus to seek circRNAs-targeted strategies.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

Liu

et al. 2020

J Cellular Molecular Medi

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Circular RNAs (circRNAs) are a group of non-coding RNAs implicated in the pathogenesis of cancer progression, which exert their functions via regulation of microRNAs (miRNAs) and genes. The present study uses gain-and loss-of-function approaches to evaluate the functions of hsa_circRNA_002178 in angiogenesis along with energy metabolism and underlying downstream signals. The expression pattern of hsa_cir-cRNA_002178 in clinical breast cancer tissues and its association with prognosis were characterized at first. Next, the energy metabolism and angiogenesis as well as cell viability were evaluated when the expression of hsa_circRNA_002178 in breast cancer cells was knocked down by siRNA. The interaction between hsa_circRNA_002178 and its downstream miR-328-3p was identified, followed by the analysis of their functions in regulation of breast cancer cellular behaviours. The target gene of miR-328-3p was predicted and verified, followed by identifying its role in the breast cancer progression. Higher expression of hsa_circRNA_002178 shared an association with worse prognosis in breast cancer. The inhibition of hsa_circRNA_002178 resulted in reductions in cell viability, energy metabolism and tube formation ability.Hsa_circRNA_002178 could competitively bind to miR-328-3p and down-regulated its expression. Restoration of miR-328-3p eliminated the tumour-promoting effects of hsa_circRNA_002178. COL1A1, as a target of miR-328-3p, could be up-regulated by overexpression of hsa_circRNA_002178. In vivo experiments further confirmed the inhibition of tumour growth and inflammation by silencing hsa_circRNA_002178 or up-regulating miR-328-3p. Taken together, hsa_circRNA_002178 is highlighted as a promising target for breast cancer due to the anti-tumour effects achieved by silencing hsa_circRNA_002178. K E Y W O R D S angiogenesis, breast cancer, circular RNA, COL1A1, energy metabolism, Hsa_ circRNA_002178, MicroRNA-328-3p Additional supporting information may be found online in the Supporting Information section. How to cite this article: Liu T, Ye P, Ye Y, Lu S, Han B. Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

Liu

et al. 2020

J Cellular Molecular Medi

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“…CircRNAs also participated in the biological functions and progression of BC, such as tumorigenesis, proliferation, apoptosis, cell cycle, vascularization, invasion, migration and metastasis. [61][62][63][64][65] For example, circ_001569 was identified to be associated with clinical-pathological features and prognosis in BC patients, and knockdown of circ_001569 remarkably inhibited the activation of PI3-K/Akt signal pathway, 66 Moreover, circRNA-MTO1 (also known as circRNA-007874) could significantly suppress cell viability and reverse monastrol resistance in BC. Mechanistic studies showed that circRNA-MTO1 reduced the Eg5 protein expression but not mRNA level through preventing TNFα receptor-associated factor (TRAF) 4 from activating Eg5 translation.…”

Section: Breast Cancermentioning

confidence: 99%

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Tang

Hann

2020

OTT

133

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Circular RNA (circRNA) is an intriguing class of RNA with covalently closedloop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.

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“…For example, Liu et al found that exosomal circRNA 100284 was involved in malignant transformation of human hepatic cells [11]. Several recent studies indicated that cir-cRNAs performs its function in cancers by acting as sponges of microRNAs (miRNAs), including glioma, breast cancer and lung cancer [12,13]. However, the role of exosomal circRNAs in LUSC patients has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets

et al. 2020

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Emerging evidences indicated that exosomal circular RNAs (circRNAs) could serve as diagnostic biomarkers for cancers. However, the expression profiles and clinical significance of circRNAs in lung squamous cell carcinoma (LUSC) remain largely unknown. Herein, we analyzed circRNAs expression profile in six pairs of plasma exosome samples of LUSC patients using high-throughput sequencing. A total of 252 differentially expressed exosomal circRNAs were identified, including 133 up-regulated circRNAs and 119 down-regulated circRNAs. Subsequently, the circRNAs–miRNAs–mRNAs interaction network was built to investigate potential function of circRNAs. Three up-regulated circRNAs (hsa_circ_0014235, hsa_circ_0025580 and hsa_circ_0026403) were implied to participate in cancer-related pathways. QRT-PCR experiment confirmed the up-regulation of hsa_circ_0014235 and hsa_circ_0025580. Finally, clinical studies indicated that hsa_circ_0014235 and hsa_circ_0025580 could serve as novel diagnostic biomarkers for LUSC. Taken together, our study revealed exosomal circRNAs expression profile in LUSC for the first time and showed the important diagnostic potential for circRNAs in LUSC.

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Advances in circular RNAs and their roles in breast Cancer

Cited by 97 publications

References 100 publications

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets

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